Tsnax translin-associated factor X [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tsnaxprovided by RGD
Official Full Name: translin-associated factor Xprovided by RGD
Primary source: RGD:621574
See related: EnsemblRapid:ENSRNOG00000049784 AllianceGenome:RGD:621574
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trax
Summary: Enables A2A adenosine receptor binding activity. Contributes to sequence-specific DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in siRNA processing. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of endoribonuclease complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human TSNAX (translin associated factor X). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 296.2), Heart (RPKM 248.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (69873210..69887244)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (52975848..52989886)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (57771539..57785567)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLCbeta through its ability to bind TRAX plays a key role in switching PC12 cells to their differentiated state.
Title: Phospholipase Cβ-TRAX Association Is Required for PC12 Cell Differentiation.
Studies show that TRAX, localized in the cytosol and nucleus, competes with plasma-membrane bound Galpha(q) for PLCbeta1 binding thus stabilizing PLCbeta1 in other cellular compartments.
Title: Identification of a novel binding partner of phospholipase cβ1: translin-associated factor X.
A(2A)-R modulates the differentiation ability of trophic factors through a novel interacting protein, TRAX.
Title: Rescue of p53 blockage by the A(2A) adenosine receptor via a novel interacting protein, translin-associated protein X.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:98954

NoName (e-PCR)
- UniSTS:98955

BE111581 (e-PCR)
- UniSTS:245698

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables A2A adenosine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in siRNA processing	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of endoribonuclease complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: translin-associated protein X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022262.3 → NP_071598.1 translin-associated protein X

See identical proteins and their annotated locations for NP_071598.1

Status: PROVISIONAL

Source sequence(s)

BC081715

UniProtKB/Swiss-Prot

Q9JHB5

UniProtKB/TrEMBL

A6KJ28

Related

ENSRNOP00000063911.1, ENSRNOT00000071827.4

Conserved Domains (1) summary

cl00957
Location:42 → 256

Translin-like; Translin and translin-associated factor-X (TRAX)