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    Zfyve1 zinc finger FYVE-type containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299188, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfyve1provided by RGD
    Official Full Name
    zinc finger FYVE-type containing 1provided by RGD
    Primary source
    RGD:1307795
    See related
    EnsemblRapid:ENSRNOG00000008614 AllianceGenome:RGD:1307795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in several processes, including cellular response to starvation; lipid droplet formation; and positive regulation by host of viral genome replication. Predicted to be located in several cellular components, including autophagosome; mitochondria-associated endoplasmic reticulum membrane contact site; and omegasome. Predicted to be extrinsic component of omegasome membrane. Predicted to be active in lipid droplet. Orthologous to human ZFYVE1 (zinc finger FYVE-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 83.4), Testes (RPKM 74.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfyve1 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (108916062..108965231, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103184938..103234111, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107031411..107080590, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene double PHD fingers 3 Neighboring gene uncharacterized LOC134479225 Neighboring gene uncharacterized LOC134479227 Neighboring gene uncharacterized LOC134479226 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene uncharacterized LOC102547293 Neighboring gene RNA binding motif protein 25 Neighboring gene presenilin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Hayashi-Nishino M, et al. Nat Cell Biol, 2009 Dec. PMID 19898463
    2. Cellular localization and tissue distribution of endogenous DFCP1 protein. Nanao T, et al. Biomed Res, 2015. PMID 25876663
    3. DFCP1 associates with lipid droplets. Gao G, et al. Cell Biol Int, 2019 Dec. PMID 31293035
    4. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. Ridley SH, et al. J Cell Sci, 2001 Nov. PMID 11739631
    5. Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. Cheung PC, et al. Biochem J, 2001 Apr 1. PMID 11256955, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extrinsic component of omegasome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in omegasome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger FYVE domain-containing protein 1
    Names
    zinc finger, FYVE domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106743.1 → NP_001100213.1  zinc finger FYVE domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001100213.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      A6JDQ1, D4A3T4
      Related
      ENSRNOP00000011662.5, ENSRNOT00000011662.7
      Conserved Domains (5) summary
      cd01851
      Location:174 → 410
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd15734
      Location:711 → 771
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:594 → 655
      FYVE_like_SF; FYVE domain like superfamily
      cd19819
      Location:16 → 63
      Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
      cd19820
      Location:69 → 122
      Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

    2. NM_001434296.1 → NP_001421225.1  zinc finger FYVE domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDQ1, D4A3T4

    3. NM_001434297.1 → NP_001421226.1  zinc finger FYVE domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDQ1, D4A3T4

    4. NM_001434298.1 → NP_001421227.1  zinc finger FYVE domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDQ1, D4A3T4

    5. NM_001434299.1 → NP_001421228.1  zinc finger FYVE domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      108916062..108965231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261729.1 → XP_063117799.1  zinc finger FYVE domain-containing protein 1 isoform X2

    2. XM_039112024.2 → XP_038967952.1  zinc finger FYVE domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd01851
      Location:174 → 410
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd15734
      Location:722 → 782
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:594 → 655
      FYVE_like_SF; FYVE domain like superfamily
      cd19819
      Location:16 → 63
      Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
      cd19820
      Location:69 → 122
      Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

    3. XM_006240323.5 → XP_006240385.1  zinc finger FYVE domain-containing protein 1 isoform X2

      Conserved Domains (5) summary
      cd01851
      Location:174 → 410
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd15734
      Location:711 → 771
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:594 → 655
      FYVE_like_SF; FYVE domain like superfamily
      cd19819
      Location:16 → 63
      Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
      cd19820
      Location:69 → 122
      Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

    4. XM_063261730.1 → XP_063117800.1  zinc finger FYVE domain-containing protein 1 isoform X2

    5. XM_039112023.2 → XP_038967951.1  zinc finger FYVE domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd01851
      Location:174 → 410
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd15734
      Location:722 → 782
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:594 → 655
      FYVE_like_SF; FYVE domain like superfamily
      cd19819
      Location:16 → 63
      Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
      cd19820
      Location:69 → 122
      Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

    6. XM_039112025.2 → XP_038967953.1  zinc finger FYVE domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd01851
      Location:174 → 410
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd15734
      Location:722 → 782
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:594 → 655
      FYVE_like_SF; FYVE domain like superfamily
      cd19819
      Location:16 → 63
      Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
      cd19820
      Location:69 → 122
      Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

    7. XM_063261732.1 → XP_063117802.1  zinc finger FYVE domain-containing protein 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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