Stradb STE20 related adaptor beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stradbprovided by RGD
Official Full Name: STE20 related adaptor betaprovided by RGD
Primary source: RGD:1559449
See related: EnsemblRapid:ENSRNOG00000010728 AllianceGenome:RGD:1559449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Als2cr2; RGD1559449
Summary: Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in activation of protein kinase activity and protein export from nucleus. Predicted to act upstream of or within JNK cascade; cell morphogenesis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in aggresome; cytosol; and nucleus. Predicted to be part of serine/threonine protein kinase complex. Orthologous to human STRADB (STE20 related adaptor beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 287.0), Kidney (RPKM 204.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q31

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (67908277..67927224)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (60414182..60433084)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (65763437..65782513)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
NOT involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of serine/threonine protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: STE20-related kinase adapter protein beta

Names: STE20-related kinase adaptor beta; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; polyploidy associated protein kinase PAPK-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109307.2 → NP_001102777.2 STE20-related kinase adapter protein beta

See identical proteins and their annotated locations for NP_001102777.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AK98, A6IP88, D3ZVH0

Related

ENSRNOP00000049160.2, ENSRNOT00000043558.4

Conserved Domains (2) summary

smart00220
Location:58 → 369

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd08226
Location:59 → 386

PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

67908277..67927224

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084089.2 → XP_038940017.1 STE20-related kinase adapter protein beta isoform X1

UniProtKB/TrEMBL

A0A8I6AK98

Conserved Domains (1) summary

cl21453
Location:59 → 357

PKc_like; Protein Kinases, catalytic domain