U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dock7 dedicator of cytokinesis 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313388, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dock7provided by RGD
    Official Full Name
    dedicator of cytokinesis 7provided by RGD
    Primary source
    RGD:1309790
    See related
    EnsemblRapid:ENSRNOG00000008298 AllianceGenome:RGD:1309790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of cold-induced thermogenesis; and nervous system development. Predicted to act upstream of or within hematopoietic progenitor cell differentiation and pigmentation. Predicted to be part of COP9 signalosome. Predicted to be active in neuromuscular junction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 129.9), Heart (RPKM 123.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dock7 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (118714863..118898362, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (113599371..113782871, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (117595194..117780844, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 15, pseudogene 2 Neighboring gene ubiquitin specific peptidase 1 Neighboring gene angiopoietin-like 3 Neighboring gene noelin-like Neighboring gene ribosomal protein L15, pseudogene 14 Neighboring gene autophagy related 4C, cysteine peptidase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells. Majewski Ł, et al. Biochem Cell Biol, 2012 Aug. PMID 22475431
    2. Altered thermogenesis and impaired bone remodeling in Misty mice. Motyl KJ, et al. J Bone Miner Res, 2013 Sep. PMID 23553822, Free PMC Article
    3. Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. Sobczak M, et al. Biochim Biophys Acta, 2016 Jul. PMID 27018747
    4. The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Watabe-Uchida M, et al. Neuron, 2006 Sep 21. PMID 16982419
    5. DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Yang YT, et al. Nat Neurosci, 2012 Sep. PMID 22842144, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC189434

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of neuroblast polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interkinetic nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pigmentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic specialization assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dedicator of cytokinesis protein 7

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415885.1 → NP_001402814.1  dedicator of cytokinesis protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K3H2
      Related
      ENSRNOP00000089895.2, ENSRNOT00000100273.2

    2. NM_001415886.1 → NP_001402815.1  dedicator of cytokinesis protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      118714863..118898362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287647.1 → XP_063143717.1  dedicator of cytokinesis protein 7 isoform X5

    2. XM_063287651.1 → XP_063143721.1  dedicator of cytokinesis protein 7 isoform X9

    3. XM_063287646.1 → XP_063143716.1  dedicator of cytokinesis protein 7 isoform X4

    4. XM_063287644.1 → XP_063143714.1  dedicator of cytokinesis protein 7 isoform X2

      Related
      ENSRNOP00000063286.3, ENSRNOT00000065112.4

    5. XM_063287645.1 → XP_063143715.1  dedicator of cytokinesis protein 7 isoform X3

      Related
      ENSRNOP00000098970.1, ENSRNOT00000156393.1

    6. XM_063287643.1 → XP_063143713.1  dedicator of cytokinesis protein 7 isoform X1

      Related
      ENSRNOP00000072637.3, ENSRNOT00000081971.3

    7. XM_063287649.1 → XP_063143719.1  dedicator of cytokinesis protein 7 isoform X7

    8. XM_063287648.1 → XP_063143718.1  dedicator of cytokinesis protein 7 isoform X6

    9. XM_063287650.1 → XP_063143720.1  dedicator of cytokinesis protein 7 isoform X8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191574.2: Suppressed sequence

      Description
      NM_001191574.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools