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    Tmem120a transmembrane protein 120A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288591, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem120aprovided by RGD
    Official Full Name
    transmembrane protein 120Aprovided by RGD
    Primary source
    RGD:1311474
    See related
    EnsemblRapid:ENSRNOG00000001441 AllianceGenome:RGD:1311474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmpit; RGD1311474
    Summary
    Predicted to enable monoatomic ion channel activity. Predicted to be involved in several processes, including detection of mechanical stimulus involved in sensory perception of pain; fat cell differentiation; and protein complex oligomerization. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human TMEM120A (transmembrane protein 120A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 172.2), Kidney (RPKM 158.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tmem120a in Genome Data Viewer
    Location:
    12q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26578859..26587524)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (20942243..20950908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23989596..23998257)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352435 Neighboring gene malate dehydrogenase 2 Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene cytochrome p450 oxidoreductase Neighboring gene rhomboid domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coenzyme A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables coenzyme A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein heterooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ion channel TACAN
    Names
    transmembrane protein induced by tumor necrosis factor alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010945.2NP_001010945.1  ion channel TACAN

      See identical proteins and their annotated locations for NP_001010945.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q5HZE2
      UniProtKB/TrEMBL
      A0A8L2Q0W8, A6J0B8
      Related
      ENSRNOP00000001960.6, ENSRNOT00000001960.9
      Conserved Domains (1) summary
      pfam07851
      Location:13336
      TMPIT; TMPIT-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      26578859..26587524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)