Wee1 WEE1 G2 checkpoint kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wee1provided by RGD
Official Full Name: WEE1 G2 checkpoint kinaseprovided by RGD
Primary source: RGD:1307895
See related: EnsemblRapid:ENSRNOG00000010017 AllianceGenome:RGD:1307895
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein tyrosine kinase activity. Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle. Predicted to act upstream of or within several processes, including establishment of cell polarity; neuron projection morphogenesis; and peptidyl-tyrosine phosphorylation. Predicted to be located in nucleolus. Predicted to be active in cytoplasm and nucleus. Orthologous to human WEE1 (WEE1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 65.2), Thymus (RPKM 58.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (173605609..173632450)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (164173681..164197688)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (174765228..174790882)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
Title: Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
Data suggest that the increase of Wee 1 tyrosine kinase but decrease of early mitotic inhibitor 2 level triggers maturation promoting factor (MPF) destabilization and thereby postovulatory aging-mediated abortive spontaneous egg activation in eggs.
Title: Maturation promoting factor destabilization facilitates postovulatory aging-mediated abortive spontaneous egg activation in rat.
identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.
Title: Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons.
Title: Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.
rhythmic profiles of the clock gene Wee1 expression within the epithelium from different parts of the rat gut exhibited a difference in phasing.
Title: Temporal gradient in the clock gene and cell-cycle checkpoint kinase Wee1 expression along the gut.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_17360-17361:1021651098:1 (e-PCR)
- UniSTS:268284

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: wee1-like protein kinase

Names: wee 1 homolog; wee1 tyrosine kinase; wee1A kinase

NP_001012760.1

EC 2.7.10.2

XP_006230036.1

EC 2.7.10.2

XP_017444692.1

EC 2.7.10.2

XP_063119123.1

EC 2.7.10.2

XP_063119130.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012742.1 → NP_001012760.1 wee1-like protein kinase

See identical proteins and their annotated locations for NP_001012760.1

Status: PROVISIONAL

Source sequence(s)

BC090346

UniProtKB/Swiss-Prot

Q5EAN3, Q63802

UniProtKB/TrEMBL

A6I810

Related

ENSRNOP00000013362.3, ENSRNOT00000013362.7

Conserved Domains (1) summary

cd14138
Location:292 → 567

PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

173605609..173632450

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229974.5 → XP_006230036.1 wee1-like protein kinase isoform X2

UniProtKB/TrEMBL

A0A8I5ZT95

Related

ENSRNOP00000081602.1, ENSRNOT00000118795.2

Conserved Domains (2) summary

cd14138
Location:292 → 567

PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a

pfam00069
Location:298 → 568

Pkinase; Protein kinase domain
XM_063263053.1 → XP_063119123.1 wee1-like protein kinase isoform X1

UniProtKB/Swiss-Prot

Q5EAN3, Q63802

UniProtKB/TrEMBL

A6I810
XM_063263060.1 → XP_063119130.1 wee1-like protein kinase isoform X3
XM_017589203.3 → XP_017444692.1 wee1-like protein kinase isoform X3