Fgf11 fibroblast growth factor 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf11provided by MGI
Official Full Name: fibroblast growth factor 11provided by MGI
Primary source: MGI:MGI:109167
See related: Ensembl:ENSMUSG00000042826 AllianceGenome:MGI:109167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fhf3; Fgf1d; Fhf-3; Fgf-11
Summary: Predicted to enable sodium channel regulator activity. Predicted to be involved in neurogenesis and regulation of voltage-gated sodium channel activity. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human FGF11 (fibroblast growth factor 11). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in cerebellum adult (RPKM 10.9), CNS E18 (RPKM 7.4) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.88 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69686894..69693775, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69796068..69802944, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of hypothalamic FGF11 prevents diet-induced obesity.
Title: Silencing of hypothalamic FGF11 prevents diet-induced obesity.
Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse.
Title: Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse.
FGF11 indirectly controls the expression of PPARgamma through modifying the expression of multiple PPARgamma regulators, thereby mediating adipogenesis.
Title: FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPARγ regulators.
endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. From a mechanistic standpoint, miR-342-3p promoted the transactivation of fibroblast growth factor 11 (FGF11) by directly targeting its 3' untranslated regions (3'UTRs).
Title: T2DM inhibition of endothelial miR-342-3p facilitates angiogenic dysfunction via repression of FGF11 signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Markers

Fgf11 (e-PCR), detects polymorphism
- UniSTS:507914

Fgf11 (e-PCR), detects polymorphism
- UniSTS:546575

Fgf11 (e-PCR), detects polymorphism
- UniSTS:516627

Fgf11 (e-PCR), detects polymorphism
- UniSTS:258257

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor 11

Names: fibroblast growth factor 1d; fibroblast growth factor homologous factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291104.2 → NP_001278033.1 fibroblast growth factor 11 isoform 2

Status: VALIDATED

Source sequence(s)

AL603707, U66203

Consensus CDS

CCDS70218.1

UniProtKB/TrEMBL

Q6NXW2

Related

ENSMUSP00000011285.5, ENSMUST00000011285.11

Conserved Domains (1) summary

cl00060
Location:69 → 171

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
NM_001362623.1 → NP_001349552.1 fibroblast growth factor 11 isoform 1

Status: VALIDATED

Source sequence(s)

AL603707

Consensus CDS

CCDS24911.1

UniProtKB/Swiss-Prot

P70378, Q5F291

UniProtKB/TrEMBL

A0A7U3L4H2

Related

ENSMUSP00000099645.2, ENSMUST00000102585.2

Conserved Domains (1) summary

smart00442
Location:69 → 199

FGF; Acidic and basic fibroblast growth factor family
NM_001362624.1 → NP_001349553.1 fibroblast growth factor 11 isoform 3

Status: VALIDATED

Source sequence(s)

AL603707

Conserved Domains (1) summary

smart00442
Location:69 → 199

FGF; Acidic and basic fibroblast growth factor family
NM_001430988.1 → NP_001417917.1 fibroblast growth factor 11 isoform 2

Status: VALIDATED

Source sequence(s)

AL603707

UniProtKB/TrEMBL

Q6NXW2
NM_010198.3 → NP_034328.1 fibroblast growth factor 11 isoform 1

Status: VALIDATED

Source sequence(s)

AL603707, U66203

Consensus CDS

CCDS24911.1

UniProtKB/Swiss-Prot

P70378, Q5F291

UniProtKB/TrEMBL

A0A7U3L4H2

Conserved Domains (1) summary

smart00442
Location:69 → 199

FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69686894..69693775 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532188.5 → XP_006532251.1 fibroblast growth factor 11 isoform X2

Conserved Domains (1) summary

cl00060
Location:69 → 171

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
XM_011248722.3 → XP_011247024.1 fibroblast growth factor 11 isoform X1

Conserved Domains (1) summary

smart00442
Location:69 → 207

FGF; Acidic and basic fibroblast growth factor family
XM_011248721.3 → XP_011247023.1 fibroblast growth factor 11 isoform X1

Conserved Domains (1) summary

smart00442
Location:69 → 207

FGF; Acidic and basic fibroblast growth factor family