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    NRK Nik related kinase [ Homo sapiens (human) ]

    Gene ID: 203447, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NRKprovided by HGNC
    Official Full Name
    Nik related kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:25391
    See related
    Ensembl:ENSG00000123572 MIM:300791; AllianceGenome:HGNC:25391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NESK
    Summary
    The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]
    Expression
    Biased expression in ovary (RPKM 15.5), placenta (RPKM 15.0) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NRK in Genome Data Viewer
    Location:
    Xq22.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (105821786..105958610)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (104253759..104390422)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (105066532..105202602)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein like 2 Neighboring gene uncharacterized LOC107985680 Neighboring gene NANOG hESC enhancer GRCh37_chrX:104880562-104881086 Neighboring gene NANOG hESC enhancer GRCh37_chrX:104892408-104892914 Neighboring gene uncharacterized LOC105373303 Neighboring gene RNA, U6 small nuclear 207, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:105065433-105066413 Neighboring gene uncharacterized LOC105373304 Neighboring gene HNF1 motif-containing MPRA enhancer 3 Neighboring gene uncharacterized LOC105373305 Neighboring gene serpin family A member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate. He W, et al. J Transl Med, 2024 Mar 9. PMID 38459501, Free PMC Article
    2. Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment. Wei T, et al. J Cancer Res Clin Oncol, 2021 Apr. PMID 33387038
    3. Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice. Yanagawa T, et al. Am J Pathol, 2016 Oct. PMID 27634343
    4. Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family. Nakano K, et al. Exp Cell Res, 2003 Jul 15. PMID 12837278
    5. Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP. Naito S, et al. FEBS Lett, 2020 Jun. PMID 32162334

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate.
      Title: Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate.
    2. Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.
      Title: Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.
    3. Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment.
      Title: Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment.
    4. The results suggest that Nrk suppresses the excessive proliferation of mammary epithelial cells during pregnancy, and the impairment of this regulatory system leads to frequent occurrence of breast tumor in Nrk mutant mice.
      Title: Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16788, MGC131849, DKFZp686A17109

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nik-related protein kinase
    NP_940867.2
    XP_006724695.1
    XP_006724696.1
    XP_006724697.1
    XP_011529189.1
    XP_054182632.1
    XP_054182633.1
    XP_054182634.1
    XP_054182635.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021425.2 RefSeqGene

      Range
      4997..141068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_198465.4 → NP_940867.2  nik-related protein kinase

      See identical proteins and their annotated locations for NP_940867.2

      Status: REVIEWED

      Source sequence(s)
      BX538345, KF459287, Z68339, Z69734, Z70274, Z83850
      Consensus CDS
      CCDS65305.1
      UniProtKB/Swiss-Prot
      Q32ND6, Q5H9K2, Q6ZMP2, Q7Z2Y5
      Related
      ENSP00000434830.1, ENST00000243300.14
      Conserved Domains (3) summary
      smart00220
      Location:25 → 313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:1213 → 1549
      CNH; CNH domain
      cl21453
      Location:18 → 313
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      105821786..105958610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530887.4 → XP_011529189.1  nik-related protein kinase isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:29 → 258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:1158 → 1494
      CNH; CNH domain
      cl21453
      Location:29 → 258
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006724632.4 → XP_006724695.1  nik-related protein kinase isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:25 → 313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:1213 → 1541
      CNH; CNH domain
      cl21453
      Location:18 → 313
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006724633.4 → XP_006724696.1  nik-related protein kinase isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:25 → 313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:1213 → 1501
      CNH; CNH domain
      cl21453
      Location:18 → 313
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006724634.5 → XP_006724697.1  nik-related protein kinase isoform X4

      Conserved Domains (3) summary
      smart00220
      Location:25 → 313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:1213 → 1493
      CNH; CNH domain
      cl21453
      Location:18 → 313
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      104253759..104390422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326660.1 → XP_054182635.1  nik-related protein kinase isoform X3

    2. XM_054326657.1 → XP_054182632.1  nik-related protein kinase isoform X1

    3. XM_054326658.1 → XP_054182633.1  nik-related protein kinase isoform X2

    4. XM_054326659.1 → XP_054182634.1  nik-related protein kinase isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z2Y5.2 GenPept UniProtKB/Swiss-Prot:Q7Z2Y5

    Gene LinkOut

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