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    MAP1A microtubule associated protein 1A [ Homo sapiens (human) ]

    Gene ID: 4130, updated on 9-Dec-2024

    Summary

    Official Symbol
    MAP1Aprovided by HGNC
    Official Full Name
    microtubule associated protein 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:6835
    See related
    Ensembl:ENSG00000166963 MIM:600178; AllianceGenome:HGNC:6835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAP1L; MTAP1A
    Summary
    This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 73.0), heart (RPKM 5.9) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAP1A in Genome Data Viewer
    Location:
    15q15.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43510954..43531611)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (41318305..41338962)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43803152..43823809)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex component 4 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene Neighboring gene tumor protein p53 binding protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:43734212-43734815 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43769402-43769643 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:43784380-43785088 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:43785089-43785795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43787292-43787792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43810281-43810924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43819912-43820544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43821526-43822026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43822027-43822527 Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene creatine kinase, mitochondrial 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of MAP1A by shRNA inhibits HIV-1 infectivity in human PBMCs PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag MAP1A and MAP1S proteins activate HIV-1 retrograde trafficking by tethering capsids to microtubules in primary human macrophages PubMed
    gag MAP1A and MAP1S depletion leads to an accumulation of HIV-1 CA labelling throughout the cytoplasm, suggesting an inability both to reach the nuclear membrane and to uncoat PubMed
    gag MAP1A and MAP1S proteins interact with HIV-1 CA cores in primary human macrophages PubMed
    retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ77111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cytoskeletal anchor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables tau protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in associative learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein localization to microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein localization to cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde axonal protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in voluntary musculoskeletal movement ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon initial segment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic branch ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in primary dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    microtubule-associated protein 1A
    Names
    MAP-1A
    proliferation-related protein p80

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411089.1NP_001398018.1  microtubule-associated protein 1A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC018924, AC019011
      Consensus CDS
      CCDS91988.1
      UniProtKB/TrEMBL
      E9PGC8
      Related
      ENSP00000371462.1, ENST00000382031.5
    2. NM_002373.6NP_002364.5  microtubule-associated protein 1A isoform 1

      See identical proteins and their annotated locations for NP_002364.5

      Status: REVIEWED

      Source sequence(s)
      AC019011, AI124707, BC094702, BP309709
      Consensus CDS
      CCDS42031.1
      UniProtKB/Swiss-Prot
      O95643, P78559, Q12973, Q15882, Q9UJT4
      Related
      ENSP00000300231.5, ENST00000300231.6
      Conserved Domains (4) summary
      pfam12718
      Location:13971540
      Tropomyosin_1; Tropomyosin like
      cd16269
      Location:14561470
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:13641488
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23716
      Location:50101
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      43510954..43531611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      41318305..41338962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)