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    TRIM31 tripartite motif containing 31 [ Homo sapiens (human) ]

    Gene ID: 11074, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TRIM31provided by HGNC
    Official Full Name
    tripartite motif containing 31provided by HGNC
    Primary source
    HGNC:HGNC:16289
    See related
    Ensembl:ENSG00000204616 MIM:609316; AllianceGenome:HGNC:16289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF; HCG1; HCGI; C6orf13
    Summary
    This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in colon (RPKM 26.2), urinary bladder (RPKM 20.1) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM31 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30102897..30113090, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29967171..29977357, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30070674..30080867, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene POLR1H antisense, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30028069-30028935 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30028936-30029801 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 11 Neighboring gene RNA polymerase I subunit H Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30041647-30042322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30042323-30042996 Neighboring gene ring finger protein 39 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30068196-30068705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30070193-30070692 Neighboring gene TRIM31 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:30080310-30081509 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene tripartite motif containing 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRIM31 promotes the progression of oral squamous cell carcinoma through upregulating AKT phosphorylation and subsequent cellular glycolysis. Sang SQ, et al. Neoplasma, 2023 Jun. PMID 37498068
    2. TRIM31 promotes acute myeloid leukemia progression and sensitivity to daunorubicin through the Wnt/β-catenin signaling. Xiao Y, et al. Biosci Rep, 2020 Apr 30. PMID 32232394, Free PMC Article
    3. Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis. Guo P, et al. Exp Cell Res, 2018 Jul 1. PMID 29665353
    4. TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1-TSC2 complex. Guo P, et al. Oncogene, 2018 Jan 25. PMID 28967907
    5. Characterization of TRIM31, upregulated in gastric adenocarcinoma, as a novel RBCC protein. Sugiura T, et al. J Cell Biochem, 2008 Nov 1. PMID 18773414

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer.
      Title: An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer.
    2. TRIM31 promotes the progression of oral squamous cell carcinoma through upregulating AKT phosphorylation and subsequent cellular glycolysis.
      Title: TRIM31 promotes the progression of oral squamous cell carcinoma through upregulating AKT phosphorylation and subsequent cellular glycolysis.
    3. Tripartite motif-containing protein 31 confers protection against nonalcoholic steatohepatitis by deactivating mitogen-activated protein kinase kinase kinase 7.
      Title: Tripartite motif-containing protein 31 confers protection against nonalcoholic steatohepatitis by deactivating mitogen-activated protein kinase kinase kinase 7.
    4. Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling.
      Title: Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling.
    5. CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis.
      Title: CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis.
    6. Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers.
      Title: Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers.
    7. Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.
      Title: Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.
    8. TRIM31 promotes apoptosis via TAK1-mediated activation of NF-kappaB signaling in sepsis-induced myocardial dysfunction.
      Title: TRIM31 promotes apoptosis via TAK1-mediated activation of NF-κB signaling in sepsis-induced myocardial dysfunction.
    9. [Effect of TRIM31 Gene Silencing on the Proliferation and Apoptosis of U266 Cells and Its Mechanism].
      Title: [Effect of TRIM31 Gene Silencing on the Proliferation and Apoptosis of U266 Cells and Its Mechanism].
    10. TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3.
      Title: TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
    EBI GWAS Catalog
    Common genetic variation and performance on standardized cognitive tests.
    EBI GWAS Catalog
    Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.
    EBI GWAS Catalog
    Genome-wide association study of proneness to anger.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 infection is modestly restricted by human TRIM31. Gene silencing of endogenously expressed TRIM31inhibits viral release, suggesting the interaction between HIV-1 Gag and TRIM31 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of NLRP3 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral release from host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM31
    Names
    RING-type E3 ubiquitin transferase TRIM31
    tripartite motif-containing protein 31
    NP_008959.3
    XP_011512566.1
    XP_011512567.1
    XP_011512568.1
    XP_047274066.1
    XP_054185701.1
    XP_054185702.1
    XP_054185703.1
    XP_054186198.1
    XP_054186199.1
    XP_054186200.1
    XP_054186201.1
    XP_054186486.1
    XP_054186487.1
    XP_054186488.1
    XP_054186489.1
    XP_054186736.1
    XP_054186970.1
    XP_054186971.1
    XP_054186972.1
    XP_054186973.1
    XP_054187250.1
    XP_054210066.1
    XP_054210067.1
    XP_054210068.1
    XP_054210069.1
    XP_054210070.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007028.5 → NP_008959.3  E3 ubiquitin-protein ligase TRIM31

      See identical proteins and their annotated locations for NP_008959.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as alpha) represents the longest transcript and encodes the protein.
      Source sequence(s)
      AF230386, BG403536, BM847963, CB142265
      Consensus CDS
      CCDS34374.1
      UniProtKB/Swiss-Prot
      A6NLX6, A9R9Q4, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8, Q9BZY9
      UniProtKB/TrEMBL
      A0A1U9X8Q7, A0A1U9X8R1, A0A1U9X8S0, A0A1U9X8S1, A0A1U9X8T0, Q2L6J1
      Related
      ENSP00000365924.3, ENST00000376734.4
      Conserved Domains (2) summary
      smart00336
      Location:90 → 131
      BBOX; B-Box-type zinc finger
      cd16582
      Location:13 → 56
      RING-HC_TRIM31_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 31 (TRIM31) and similar proteins

    RNA

    1. NR_134870.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate segment in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK222729, CB142265, DB244000

    2. NR_134871.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as beta) lacks an exon and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF230387, CB142265, DB244000

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      30102897..30113090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418110.1 → XP_047274066.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

      UniProtKB/TrEMBL
      A0A1U9X8R1

    2. XM_011514264.2 → XP_011512566.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

      See identical proteins and their annotated locations for XP_011512566.1

      UniProtKB/TrEMBL
      A0A1U9X8R1, A0A1U9X8S0, A0A1U9X8S1, A0A1U9X8T0
      Conserved Domains (2) summary
      smart00336
      Location:90 → 131
      BBOX; B-Box-type zinc finger
      pfam15227
      Location:16 → 56
      zf-C3HC4_4; zinc finger of C3HC4-type, RING

    3. XM_011514265.2 → XP_011512567.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

      See identical proteins and their annotated locations for XP_011512567.1

      UniProtKB/TrEMBL
      A0A1U9X8R1
      Conserved Domains (2) summary
      smart00336
      Location:90 → 131
      BBOX; B-Box-type zinc finger
      pfam15227
      Location:16 → 56
      zf-C3HC4_4; zinc finger of C3HC4-type, RING

    4. XM_011514266.1 → XP_011512568.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

      See identical proteins and their annotated locations for XP_011512568.1

      UniProtKB/TrEMBL
      A0A140T9J6
      Conserved Domains (2) summary
      smart00336
      Location:90 → 131
      BBOX; B-Box-type zinc finger
      pfam15227
      Location:16 → 56
      zf-C3HC4_4; zinc finger of C3HC4-type, RING

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1368493..1371180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1582690..1592889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329726.1 → XP_054185701.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JJX2

    2. XM_054329727.1 → XP_054185702.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JJX2

    3. XM_054329728.1 → XP_054185703.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

      UniProtKB/TrEMBL
      A0A140T9J6

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      1358814..1369000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330225.1 → XP_054186200.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

      UniProtKB/TrEMBL
      A0A1U9X8R1

    2. XM_054330223.1 → XP_054186198.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X8R1

    3. XM_054330224.1 → XP_054186199.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8R1

    4. XM_054330226.1 → XP_054186201.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

      UniProtKB/TrEMBL
      A0A140T9J6

    RNA

    1. XR_008485692.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      1363614..1373800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330513.1 → XP_054186488.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

      UniProtKB/TrEMBL
      A0A1U9X8R1

    2. XM_054330511.1 → XP_054186486.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X8R1, A0A1U9X8S0, A0A1U9X8S1, A0A1U9X8T0

    3. XM_054330512.1 → XP_054186487.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8R1

    4. XM_054330514.1 → XP_054186489.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

      UniProtKB/TrEMBL
      A0A140T9J6

    RNA

    1. XR_008485697.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      1446972..1457163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330761.1 → XP_054186736.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8R1

    RNA

    1. XR_008485703.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      1358044..1368231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330997.1 → XP_054186972.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

      UniProtKB/TrEMBL
      A0A1U9X8R0, A0A1U9X8S1

    2. XM_054330995.1 → XP_054186970.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X8S1

    3. XM_054330996.1 → XP_054186971.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8R0, A0A1U9X8S1

    4. XM_054330998.1 → XP_054186973.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

      UniProtKB/TrEMBL
      A0A140T9J6

    RNA

    1. XR_008485709.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      1401829..1412013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331275.1 → XP_054187250.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8R1

    RNA

    1. XR_008485714.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      29967171..29977357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354093.1 → XP_054210068.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

      UniProtKB/TrEMBL
      A0A1U9X8R1

    2. XM_054354091.1 → XP_054210066.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X8R1

    3. XM_054354092.1 → XP_054210067.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8R1

    4. XM_054354094.1 → XP_054210069.1  E3 ubiquitin-protein ligase TRIM31 isoform X5

      UniProtKB/TrEMBL
      C4B4E3

    5. XM_054354095.1 → XP_054210070.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

      UniProtKB/TrEMBL
      A0A140T9J6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BZY9.2 GenPept UniProtKB/Swiss-Prot:Q9BZY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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