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    MND1 meiotic nuclear divisions 1 [ Homo sapiens (human) ]

    Gene ID: 84057, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MND1provided by HGNC
    Official Full Name
    meiotic nuclear divisions 1provided by HGNC
    Primary source
    HGNC:HGNC:24839
    See related
    Ensembl:ENSG00000121211 MIM:611422; AllianceGenome:HGNC:24839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAJ
    Summary
    The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 3.9), lymph node (RPKM 2.6) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MND1 in Genome Data Viewer
    Location:
    4q31.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153344649..153415118)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (156669078..156739559)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154265801..154336270)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 2 Neighboring gene RNA, U6 small nuclear 1196, pseudogene Neighboring gene annexin A2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22052 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154388523-154389188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390454-154390954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390955-154391455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154415607-154416604 Neighboring gene transmembrane 131 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154433973-154434472 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154442146-154442647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22069 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:154444154-154444994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15763 Neighboring gene uncharacterized LOC105377498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154455569-154456145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154456146-154456721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:154457236-154457741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15764 Neighboring gene toll like receptor 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154561385-154561884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15765 Neighboring gene WD repeat domain 45 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MND1 functions as a potential prognostic biomarker associated with cell cycle and immune infiltration in kidney renal clear cell carcinoma. Fang J, et al. Aging (Albany NY), 2022 Sep 10. PMID 36098680, Free PMC Article
    2. Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma. Zhang Q, et al. Cancer Commun (Lond), 2021 Jun. PMID 33734616, Free PMC Article
    3. Genetic network and gene set enrichment analyses identify MND1 as potential diagnostic and therapeutic target gene for lung adenocarcinoma. Wei J, et al. Sci Rep, 2021 May 3. PMID 33941804, Free PMC Article
    4. Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex. Enomoto R, et al. J Biol Chem, 2006 Mar 3. PMID 16407260
    5. A predicted deleterious allele of the essential meiosis gene MND1, present in ~ 3% of East Asians, does not disrupt reproduction in mice. Tran TN, et al. Mol Hum Reprod, 2019 Oct 28. PMID 31393579, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MND1 functions as a potential prognostic biomarker associated with cell cycle and immune infiltration in kidney renal clear cell carcinoma.
      Title: MND1 functions as a potential prognostic biomarker associated with cell cycle and immune infiltration in kidney renal clear cell carcinoma.
    2. Genetic network and gene set enrichment analyses identify MND1 as potential diagnostic and therapeutic target gene for lung adenocarcinoma.
      Title: Genetic network and gene set enrichment analyses identify MND1 as potential diagnostic and therapeutic target gene for lung adenocarcinoma.
    3. Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma.
      Title: Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma.
    4. Assuming the mouse model accurately reflects the impact of this variant in humans, rs140107488 appears to be a benign allele that can be eliminated or de-prioritized in clinical genomic analyses of infertility patients.
      Title: A predicted deleterious allele of the essential meiosis gene MND1, present in ~ 3% of East Asians, does not disrupt reproduction in mice.
    5. Data indicate that the positive expression of studied genes fertilization rate for GAPDHS positive subset was 66%, ACR - 71%, SPATA22 - 68%, MND1 - 70%, pregnancy rates were 8%, 6%, 18% and 36% respectively.
      Title: Expression analysis of MND1/GAJ, SPATA22, GAPDHS and ACR genes in testicular biopsies from non-obstructive azoospermia (NOA) patients.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. Data suggest that the human TBPIP/Hop2-Mnd1 complex may ensure proper pairing between homologous chromosomes through its stimulation of strand exchange during meiosis.
      Title: Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of meiotic nuclear divisions 1 homolog (MND1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homologous chromosome pairing at meiosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    meiotic nuclear division protein 1 homolog
    Names
    homolog of yeast MND1
    meiotic nuclear divisions 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253861.1 → NP_001240790.1  meiotic nuclear division protein 1 homolog isoform 2

      See identical proteins and their annotated locations for NP_001240790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA542845, BG613292, BM820228, BU533354
      Consensus CDS
      CCDS75202.1
      UniProtKB/TrEMBL
      A0A087WTC6, D6RCT6
      Related
      ENSP00000477758.1, ENST00000622785.4
      Conserved Domains (1) summary
      pfam03962
      Location:17 → 119
      Mnd1; Mnd1 family

    2. NM_032117.4 → NP_115493.1  meiotic nuclear division protein 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_115493.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA542845, AC013477, AK312172, BM820228, BU533354
      Consensus CDS
      CCDS3782.1
      UniProtKB/Swiss-Prot
      B2R5F9, Q9BWT6
      Related
      ENSP00000240488.3, ENST00000240488.8
      Conserved Domains (1) summary
      pfam03962
      Location:17 → 202
      Mnd1; Mnd1 family

    RNA

    1. NR_045605.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes two alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA542845, AC013477, BF975093, BG758047, BU533354

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      153344649..153415118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263275.3 → XP_005263332.1  meiotic nuclear division protein 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_005263332.1

      Conserved Domains (2) summary
      COG5124
      Location:5 → 189
      COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
      pfam03962
      Location:16 → 187
      Mnd1; Mnd1 family

    2. XM_047416247.1 → XP_047272203.1  meiotic nuclear division protein 1 homolog isoform X3

    3. XM_047416246.1 → XP_047272202.1  meiotic nuclear division protein 1 homolog isoform X2

      UniProtKB/TrEMBL
      D6RIA0
      Related
      ENSP00000427559.1, ENST00000509752.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      156669078..156739559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350970.1 → XP_054206945.1  meiotic nuclear division protein 1 homolog isoform X1

    2. XM_054350971.1 → XP_054206946.1  meiotic nuclear division protein 1 homolog isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BWT6.1 GenPept UniProtKB/Swiss-Prot:Q9BWT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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