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    Ereg epiregulin [ Mus musculus (house mouse) ]

    Gene ID: 13874, updated on 4-Jan-2025

    Summary

    Official Symbol
    Eregprovided by MGI
    Official Full Name
    epiregulinprovided by MGI
    Primary source
    MGI:MGI:107508
    See related
    Ensembl:ENSMUSG00000029377 AllianceGenome:MGI:107508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EPR
    Summary
    Enables epidermal growth factor receptor binding activity; receptor ligand activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of mitotic nuclear division. Located in extracellular space. Is expressed in several structures, including extraembryonic component; heart; lung; ovary; and skin. Human ortholog(s) of this gene implicated in extrapulmonary tuberculosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human EREG (epiregulin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in large intestine adult (RPKM 1.5), bladder adult (RPKM 1.0) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Ereg in Genome Data Viewer
    Location:
    5 E1; 5 44.78 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (91222476..91241508)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (91074617..91093649)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Neighboring gene predicted gene, 52819 Neighboring gene epithelial mitogen Neighboring gene predicted gene, 19610 Neighboring gene STARR-seq mESC enhancer starr_13611 Neighboring gene amphiregulin Neighboring gene predicted gene, 23092

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC36144

    Gene Ontology Provided by MGI

    Items 1 - 25 of 62
    Process Evidence Code Pubs
    involved_in ERBB2-EGFR signaling pathway PubMed 
    involved_in ERBB2-ERBB4 signaling pathway PubMed 
    involved_in ERBB4-ERBB4 signaling pathway PubMed 
    involved_in anatomical structure morphogenesis PubMed 
    involved_in angiogenesis  
    involved_in animal organ morphogenesis PubMed 
    involved_in cell-cell signaling  
    involved_in cell-cell signaling  
    involved_in cytokine-mediated signaling pathway  
    involved_in cytokine-mediated signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    involved_in female meiotic nuclear division  
    involved_in female meiotic nuclear division  
    involved_in keratinocyte proliferation  
    involved_in keratinocyte proliferation  
    involved_in luteinizing hormone signaling pathway  
    involved_in luteinizing hormone signaling pathway  
    involved_in mRNA transcription  
    involved_in mRNA transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of smooth muscle cell differentiation  
    involved_in negative regulation of smooth muscle cell differentiation  
    involved_in oocyte maturation  
    involved_in oocyte maturation  
    involved_in ovarian cumulus expansion  
    involved_in ovarian cumulus expansion  
    involved_in ovulation  
    involved_in ovulation  
    involved_in positive regulation of DNA replication PubMed 
    involved_in positive regulation of DNA replication  
    involved_in positive regulation of DNA replication PubMed 
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cytokine production PubMed 
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of innate immune response PubMed 
    involved_in positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of mitotic nuclear division PubMed 
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of mitotic nuclear division PubMed 
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of phosphorylation PubMed 
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in primary follicle stage  
    involved_in primary follicle stage  
    involved_in response to peptide hormone  
    Items 1 - 25 of 62
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    is_active_in extracellular space PubMed 
    is_active_in extracellular space PubMed 
    located_in extracellular space  
    located_in extracellular space  
    located_in plasma membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007950.2NP_031976.1  proepiregulin preproprotein

      See identical proteins and their annotated locations for NP_031976.1

      Status: VALIDATED

      Source sequence(s)
      AC109311, BB612312, CJ056327
      Consensus CDS
      CCDS19420.1
      UniProtKB/Swiss-Prot
      Q61521, Q7M0A8
      Related
      ENSMUSP00000031324.5, ENSMUST00000031324.6
      Conserved Domains (1) summary
      PHA03099
      Location:58141
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      91222476..91241508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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