Src64B Src oncogene at 64B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Src64Bprovided by FlyBase
Official Full Name: Src oncogene at 64Bprovided by FlyBase
Primary source: FLYBASE:FBgn0262733
Locus tag: Dmel_CG7524
See related: AllianceGenome:FB:FBgn0262733
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: c-src; c-Src; C-src1; CG7524; D-src; D-Src64B; Dm SRC1; Dmel\CG7524; DmHD-358; dsrc; dSrc; Dsrc; DSrc; Dsrc64; DSrc64; DSRC64; dSrc64B; Dsrc64B; DSrc64B; HD-358; MRE5; pSrc; src; Src; SRC; SRC 64B; src1; Src1; src64; Src64; src64b; src64B; Src64b; SRC64B
Summary: Enables non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in several processes, including cell-cell junction organization; oogenesis; and regulation of signal transduction. Located in germline ring canal. Is expressed in several structures, including Kenyon cell; adult head; brain; embryonic/larval midgut primordium; and female germline cell. Used to study cancer; carcinoma; colorectal cancer; intestinal cancer; and kidney disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer (multiple); diabetes mellitus (multiple); ductal carcinoma in situ; immunodeficiency 22; and systemic lupus erythematosus. Orthologous to several human genes including LCK (LCK proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 64B11-64B12; 3-12 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4592447..4626196, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4592447..4626196, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity.
Title: Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity.
Src overexpression alone activated the Jun N-terminal Kinase (JNK) signalling pathway to promote actin cytoskeletal and cell polarity defects and drive apoptosis in in a whole epithelial tissue context in the Drosophila eye, whereas, in cooperation with RasACT, JNK led to a loss of differentiation and an invasive phenotype.
Title: Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue.
Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
Title: Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline.
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction
Title: The TRIM-NHL protein Brat promotes axon maintenance by repressing src64B expression.
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
Title: Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine.
a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.
Title: c-Src drives intestinal regeneration and transformation.
Data show that the actin-Capping Protein (CP) alphabeta heterodimer, which regulates actin filament (F-actin) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK activation.
Title: Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene.
Dumbfounded/Neph1, a key diaphragm constituent, is a target of the Src kinase Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 tyrosine phosphorylation.
Title: Src64B phosphorylates Dumbfounded and regulates slit diaphragm dynamics: Drosophila as a model to study nephropathies.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
Title: Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B.
E4orf4 has a role in inducing PP2A- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster
Title: E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1868 (e-PCR)
- UniSTS:9360

Dm0562 (e-PCR)
- UniSTS:46511

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germline ring canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germline ring canal formation, actin assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germline ring canal stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filtration diaphragm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived female germ-line cyst encapsulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte karyosome formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in parallel actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Src oncogene at 64B

Names: CG7524-PB; CG7524-PC; CG7524-PD; CG7524-PE; CG7524-PF; CG7524-PH; CG7524-PI; CG7524-PJ; CG7524-PK; Src proto oncogene sequence; Src64B-PB; Src64B-PC; Src64B-PD; Src64B-PE; Src64B-PF; Src64B-PH; Src64B-PI; Src64B-PJ; Src64B-PK; mRNA-like ncRNA in embryogenesis 5

NP_001014561.1

EC 2.7.10.2

NP_001014562.1

EC 2.7.10.2

NP_001014563.1

EC 2.7.10.2

NP_001014564.1

EC 2.7.10.2

NP_001189051.1

EC 2.7.10.2

NP_001246628.1

EC 2.7.10.2

NP_001246629.1

EC 2.7.10.2

NP_001286937.1

EC 2.7.10.2

unusual splice

NP_524934.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

4592447..4626196 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259699.2 → NP_001246628.1 Src oncogene at 64B, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246628.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1H7, O18372, P00528, Q9VZA2

UniProtKB/TrEMBL

M9MSK3

Conserved Domains (3) summary

cd09933
Location:158 → 258

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:99 → 150

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:288 → 537

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_001259700.2 → NP_001246629.1 Src oncogene at 64B, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246629.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1H7, O18372, P00528, Q9VZA2

UniProtKB/TrEMBL

M9MSK3

Conserved Domains (3) summary

cd09933
Location:158 → 258

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:99 → 150

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:288 → 537

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_001300008.1 → NP_001286937.1 Src oncogene at 64B, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286937.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JCI2

Conserved Domains (3) summary

cd09933
Location:158 → 259

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:99 → 150

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:289 → 538

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_001014561.2 → NP_001014561.1 Src oncogene at 64B, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014561.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1H7, O18372, P00528, Q9VZA2

UniProtKB/TrEMBL

M9MSK3

Conserved Domains (3) summary

cd09933
Location:158 → 258

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:99 → 150

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:288 → 537

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_001014562.3 → NP_001014562.1 Src oncogene at 64B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014562.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1H7, O18372, P00528, Q9VZA2

UniProtKB/TrEMBL

M9MSK3

Conserved Domains (3) summary

cd09933
Location:158 → 258

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:99 → 150

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:288 → 537

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_001014564.3 → NP_001014564.1 Src oncogene at 64B, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014564.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1H7, O18372, P00528, Q9VZA2

UniProtKB/TrEMBL

M9MSK3

Conserved Domains (3) summary

cd09933
Location:158 → 258

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:99 → 150

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:288 → 537

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_080195.4 → NP_524934.2 Src oncogene at 64B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524934.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1H7, O18372, P00528, Q9VZA2

UniProtKB/TrEMBL

M9MSK3

Related

FBpp0073177

Conserved Domains (3) summary

cd09933
Location:158 → 258

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:99 → 150

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:288 → 537

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_001014563.3 → NP_001014563.1 Src oncogene at 64B, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014563.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1H7, O18372, P00528, Q9VZA2

UniProtKB/TrEMBL

M9MSK3

Conserved Domains (3) summary

cd09933
Location:158 → 258

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:99 → 150

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:288 → 537

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
NM_001202122.1 → NP_001189051.1 Src oncogene at 64B, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189051.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1H7, O18372, P00528, Q9VZA2

UniProtKB/TrEMBL

M9MSK3

Conserved Domains (3) summary

cd09933
Location:158 → 258

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd11845
Location:99 → 150

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05034
Location:288 → 537

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases