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    nrv3 nervana 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nrv3provided by FlyBase
    Official Full Name
    nervana 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032946
    Locus tag
    Dmel_CG8663
    See related
    AllianceGenome:FB:FBgn0032946
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8663; Dmel\CG8663; JYbeta1; nervana3; Nrv3
    Summary
    Predicted to enable ATPase activator activity. Involved in response to auditory stimulus and sensory perception of sound. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; embryonic central brain neurons; embryonic head sensory system; and ventral nerve cord. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to several human genes including ATP1B4 (ATPase Na+/K+ transporting family member beta 4); ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); and ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nrv3 in Genome Data Viewer
    Location:
    39D2-39D2; 2-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21380000..21393319)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21380000..21393319)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 39b Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Physiological, anatomical, and behavioral changes after acoustic trauma in Drosophila melanogaster. Christie KW, et al. Proc Natl Acad Sci U S A, 2013 Sep 17. PMID 24003166, Free PMC Article
    2. Amino acid substitutions of Na,K-ATPase conferring decreased sensitivity to cardenolides in insects compared to mammals. Dalla S, et al. Insect Biochem Mol Biol, 2013 Dec. PMID 24121093
    3. Substitutions in the cardenolide binding site and interaction of subunits affect kinetics besides cardenolide sensitivity of insect Na,K-ATPase. Dalla S, et al. Insect Biochem Mol Biol, 2017 Oct. PMID 28866054
    4. A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes. Günesdogan U, et al. EMBO Rep, 2010 Oct. PMID 20814422, Free PMC Article
    5. Loss of Na(+)/K(+)-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration. Luan Z, et al. Exp Neurol, 2014 Nov. PMID 25205229, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. nrv3 functions in Johnston's organ but not in scolopale cells, suggesting neuron specificity that parallels nrv2 scolopale cell-specific support of the catalytic ATPalpha.
      Title: Cell-type-specific roles of Na+/K+ ATPase subunits in Drosophila auditory mechanosensation.
    2. Nrv3 also encodes for a functional Na,K-ATPase beta-subunit.
      Title: Developmental changes in beta-subunit composition of Na,K-ATPase in the Drosophila eye.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21383507-21383547 mobile_element_type = transposon:1360{}4176
    • Loc: 21383558-21384120 mobile_element_type = transposon:INE-1{}4141
    • Loc: 21384321-21384365 mobile_element_type = transposon:INE-1{}4142
    • Loc: 21385796-21385871 mobile_element_type = transposon:hopper{}4172
    • Loc: 21385964-21386569 mobile_element_type = transposon:hopper2{}4186

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to auditory stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of sodium:potassium-exchanging ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sodium:potassium-exchanging ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nervana 3
    Names
    CG8663-PA
    CG8663-PC
    CG8663-PD
    CG8663-PE
    Na,K-ATPase beta-subunit
    nrv3-PA
    nrv3-PC
    nrv3-PD
    nrv3-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21380000..21393319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165378.1 → NP_724339.1  nervana 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JS69, Q86NM2
      Related
      FBpp0081047, FBtr0081519
      Conserved Domains (1) summary
      pfam00287
      Location:20 → 305
      Na_K-ATPase; Sodium / potassium ATPase beta chain

    2. NM_001273746.2 → NP_001260675.1  nervana 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260675.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDX8, Q86NM2
      Conserved Domains (1) summary
      pfam00287
      Location:20 → 307
      Na_K-ATPase; Sodium / potassium ATPase beta chain

    3. NM_165379.3 → NP_724340.1  nervana 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JS69, Q86NM2
      Related
      FBpp0081048
      Conserved Domains (1) summary
      pfam00287
      Location:20 → 305
      Na_K-ATPase; Sodium / potassium ATPase beta chain

    4. NM_136264.6 → NP_610108.1  nervana 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JS69, Q86NM2
      Related
      FBpp0081046
      Conserved Domains (1) summary
      pfam00287
      Location:20 → 305
      Na_K-ATPase; Sodium / potassium ATPase beta chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDX8 M9PDX8
    Q7JS69 Q7JS69
    Q86NM2 Q86NM2

    Gene LinkOut

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