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    GABPI beta4GalNAcTB pilot [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33516, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GABPIprovided by FlyBase
    Official Full Name
    beta4GalNAcTB pilotprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031495
    Locus tag
    Dmel_CG17257
    See related
    AllianceGenome:FB:FBgn0031495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17257; Dmel\CG17257
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus. Is expressed in several structures, including adult head; brain; central nervous system; embryonic/larval gut; and endoderm. Orthologous to human ZDHHC23 (zinc finger DHHC-type palmitoyltransferase 23). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GABPI in Genome Data Viewer
    Location:
    23C5-23C5; 2-8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3030539..3032300)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3030539..3032300)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene alpha1,4-galactosyltransferase 1 Neighboring gene pre-mRNA processing factor 40 Neighboring gene Splicing factor 3b subunit 2 Neighboring gene antisense RNA:CR44147 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Seryl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene cornichon related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot. Johswich A, et al. J Cell Biol, 2009 Jan 12. PMID 19139268, Free PMC Article
    2. "Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein. Kraft B, et al. Cell Mol Life Sci, 2011 Dec. PMID 21598021, Free PMC Article
    3. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article
    4. Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense. Deng Z, et al. J Genet Genomics, 2023 Dec. PMID 37343788
    5. The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Bannan BA, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719403, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lumenal loop regions are insect-conserved and essential for GABPI-b4GalNAcTB interaction.
      Title: "Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein.
    2. beta4GalNAcTB pilot (GABPI) is required for ER export and activity of beta4GalNAcTB.
      Title: Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta4GalNAcTB pilot
    Names
    CG17257-PA
    CG17257-PB
    CG17257-PC
    CG17257-PD
    GABPI-PA
    GABPI-PB
    GABPI-PC
    GABPI-PD
    NP_001285573.1
    NP_001285574.1
    NP_608741.1
    NP_722869.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3030539..3032300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298644.1 → NP_001285573.1  beta4GalNAcTB pilot, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J6Q6
      Conserved Domains (1) summary
      pfam01529
      Location:185 → 322
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_164522.3 → NP_722869.1  beta4GalNAcTB pilot, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0C4, Q9VQK9
      Related
      FBpp0077337
      Conserved Domains (1) summary
      pfam01529
      Location:262 → 399
      zf-DHHC; DHHC palmitoyltransferase

    3. NM_134897.5 → NP_608741.1  beta4GalNAcTB pilot, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608741.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0C4, Q9VQK9
      Related
      FBpp0077336
      Conserved Domains (1) summary
      pfam01529
      Location:262 → 399
      zf-DHHC; DHHC palmitoyltransferase

    4. NM_001298645.1 → NP_001285574.1  beta4GalNAcTB pilot, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285574.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J6Q6
      Conserved Domains (1) summary
      pfam01529
      Location:185 → 322
      zf-DHHC; DHHC palmitoyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQK9 Q9VQK9
    X2J6Q6 X2J6Q6

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