CG1440 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG1440provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0030038
Locus tag: Dmel_CG1440
See related: AllianceGenome:FB:FBgn0030038
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG1440
Summary: Predicted to enable aminopeptidase activity and cysteine-type peptidase activity. Predicted to be involved in homocysteine catabolic process and response to toxic substance. Located in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult brain; epithelium; gut section; and head epidermis primordium. Orthologous to human BLMH (bleomycin hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 7E9-7E9; 1-23 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8437057..8441264)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8331090..8335297)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in homocysteine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: uncharacterized protein

Names: CG1440-PA; CG1440-PB; CG1440-PC; CG1440-PD

NP_001096906.1

EC 3.4.11.-

NP_001096907.1

EC 3.4.11.-

NP_001285018.1

EC 3.4.11.-

NP_572477.1

EC 3.4.11.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8437057..8441264

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298089.1 → NP_001285018.1 uncharacterized protein Dmel_CG1440, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285018.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JEJ0

Conserved Domains (1) summary

pfam03051
Location:102 → 547

Peptidase_C1_2; Peptidase C1-like family
NM_132249.2 → NP_572477.1 uncharacterized protein Dmel_CG1440, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572477.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3F6

Related

FBpp0071144

Conserved Domains (1) summary

pfam03051
Location:39 → 484

Peptidase_C1_2; Peptidase C1-like family
NM_001103437.1 → NP_001096907.1 uncharacterized protein Dmel_CG1440, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096907.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JV22

Conserved Domains (1) summary

pfam03051
Location:62 → 507

Peptidase_C1_2; Peptidase C1-like family
NM_001103436.1 → NP_001096906.1 uncharacterized protein Dmel_CG1440, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096906.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JV24

Conserved Domains (1) summary

cl23744
Location:1 → 364

Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...