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    Ndfip Nedd4 family interacting protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndfipprovided by FlyBase
    Official Full Name
    Nedd4 family interacting proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052177
    Locus tag
    Dmel_CG32177
    See related
    AllianceGenome:FB:FBgn0052177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.19; CG32177; CG8056; clone 2.19; Dmel\CG32177; dNdfip
    Summary
    Enables WW domain binding activity. Involved in negative regulation of Notch signaling pathway; positive regulation of Notch signaling pathway; and wing disc development. Located in late endosome. Part of ubiquitin ligase complex. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; ganglia; and head epidermis primordium. Orthologous to several human genes including NDFIP2 (Nedd4 family interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ndfip in Genome Data Viewer
    Location:
    74E4-74E4; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17647442..17654280, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17640542..17647380, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein on ecdysone puffs Neighboring gene uncharacterized protein Neighboring gene Keren Neighboring gene uncharacterized protein Neighboring gene CREB-regulated transcription coactivator Neighboring gene small non-coding RNA 641

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex. Yao W, et al. J Biol Chem, 2018 Oct 26. PMID 30213861, Free PMC Article
    2. The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye. Brown KE, et al. Dev Biol, 2007 Jul 1. PMID 17512517
    3. Drosophila Ndfip is a novel regulator of Notch signaling. Dalton HE, et al. Cell Death Differ, 2011 Jul. PMID 20966964, Free PMC Article
    4. Mechanisms of Non-canonical Signaling in Health and Disease: Diversity to Take Therapy up a Notch? Alfred V, et al. Adv Exp Med Biol, 2018. PMID 30030827
    5. The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. Li B, et al. Elife, 2018 Sep 4. PMID 30176986, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables WW domain binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nedd4 family interacting protein
    Names
    CG32177-PA
    Ndfip-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17647442..17654280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168743.3 → NP_730291.1  Nedd4 family interacting protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730291.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVJ5
      Related
      FBpp0074972
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVJ5 Q9VVJ5

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