Fdh Formaldehyde dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fdhprovided by FlyBase
Official Full Name: Formaldehyde dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0011768
Locus tag: Dmel_CG6598
See related: AllianceGenome:FB:FBgn0011768
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ADHX; ADHX_DROME; CG6598; Dmel\CG6598; fdh; gfd; gfd/odh; GSNOR; odh; Odh; ODH
Summary: Enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; S-nitrosoglutathione reductase (NADH) activity; and octanol dehydrogenase (NAD+) activity. Involved in regulation of peptidyl-cysteine S-nitrosylation and visual learning. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in AMED syndrome; alcohol dependence; asthma; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 86C7-86C7; 3-50 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10870906..10872381, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6696628..6698103, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that regulation of NO metabolism plays an important role in learning and memory.
Title: Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables S-nitrosoglutathione reductase (NADH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables octanol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in alcohol metabolic process	IC Inferred by Curator more info	PubMed
involved_in formaldehyde catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in formaldehyde catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of nitric oxide metabolic process	IC Inferred by Curator more info	PubMed
involved_in regulation of peptidyl-cysteine S-nitrosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: formaldehyde dehydrogenase

Names: ADH; CG6598-PA; Fdh-PA; glutathione-dependent formaldehyde dehydrogenase; octanol dehydrogenase

NP_524310.1

EC 1.-.-.-

EC 1.1.1.1

EC 1.1.1.284

EC 1.1.1.73

EC 1.2.1.46

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

10870906..10872381 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079586.4 → NP_524310.1 formaldehyde dehydrogenase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524310.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P46415, Q9VGV2

Related

FBpp0081767

Conserved Domains (2) summary

cd08300
Location:9 → 378

alcohol_DH_class_III; class III alcohol dehydrogenases

COG1062
Location:9 → 379

FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]