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    betaTub56D beta-Tubulin at 56D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37238, updated on 17-Dec-2024

    Summary

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    Official Symbol
    betaTub56Dprovided by FlyBase
    Official Full Name
    beta-Tubulin at 56Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0284243
    Locus tag
    Dmel_CG9277
    See related
    AllianceGenome:FB:FBgn0284243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1t; A1ZBL0_DROME; B1t; beta; BETA 56D; beta tubulin; beta-tub; beta-Tub; beta-tub 56D; beta-tub56D; beta-Tub56D; beta-tubulin; beta-tubulin56D; beta1; beta1-tub; beta1-Tubulin; beta1t; beta1tub; beta1Tub; beta56D; betaTub; betatub(56D); betaTub1; betaTub56; betatub56D; BetaTub56D; betatubulin; beta[[1]] tubulin; beta[[1]]-tubulin; CG9277; Dmbeta1; Dmel\CG9277; DTB2; l(2)k00705; T; TBB1_DROME; Tub; Tub2D; tub56D; Tub56D; TUB56D; tubulin; Tubulin
    Summary
    A structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in microtubule. Is expressed in several structures, including apodeme; ganglia; gonad; head epidermis primordium; and sensory organ cell. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness; complex cortical dysplasia with other brain malformations (multiple); congenital symmetric circumferential skin creases 1; hypomyelinating leukodystrophy 6; and torsion dystonia 4. Orthologous to several human genes including TUBB4B (tubulin beta 4B class IVb). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See betaTub56D in Genome Data Viewer
    Location:
    56D7-56D8; 2-89 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19447319..19451600, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15334824..15339105, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor-like 6 Neighboring gene Elongin C Neighboring gene uncharacterized protein Neighboring gene meiotic W68 Neighboring gene par-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of beta 1 tubulin (beta Tub56D) in Drosophila testis stem cells is regulated by a short upstream sequence while intron elements guide expression in somatic cells. Buttgereit D, et al. Mol Gen Genet, 1993 Nov. PMID 8246879
    2. Redundant enhancer elements guide beta 1 tubulin gene expression in apodemes during Drosophila embryogenesis. Buttgereit D. J Cell Sci, 1993 Jul. PMID 8408299
    3. Using Photobleaching to Measure Spindle Microtubule Dynamics in Primary Cultures of Dividing Drosophila Meiotic Spermatocytes. Savoian MS. J Biomol Tech, 2015 Jul. PMID 25802491, Free PMC Article
    4. GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation. Ayukawa R, et al. J Cell Biol, 2021 Apr 5. PMID 33544140, Free PMC Article
    5. Genetic analysis of the Drosophila beta3-tubulin gene demonstrates that the microtubule cytoskeleton in the cells of the visceral mesoderm is required for morphogenesis of the midgut endoderm. Dettman RW, et al. Dev Biol, 1996 Jul 10. PMID 8660882

    See all (282) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The model of molecular folding for the mRNP particle involving the mRNA of beta-tubulin 56D has been proposed.
      Title: [Interactions of the TREX-2 complex with mRNP particle of β-tubulin 56D gene].
    2. Our results indicate that the maternally supplied beta1-Tubulin based microtubule network is sufficient for myoblast fusion, myotube elongation and sarcomere formation both during visceral and somatic muscle development in Drosophila embryogenesis
      Title: The syncytial visceral and somatic musculature develops independently of β3-Tubulin during Drosophila embryogenesis, while maternally supplied β1-Tubulin is stable until the early steps of myoblast fusion.
    3. Codepletion of Vhl with Mgr gives partial rescue of tubulin instability, monopolar spindle formation, and loss of centrosomes.
      Title: Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability.
    4. These data reveal that beta2-tubulin has robust properties for axoneme assembly, and that axonemal specializations are embedded in both the C-terminal tail and the body of the beta2 molecule.
      Title: Axoneme specialization embedded in a "generalist" beta-tubulin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-Tubulin at 56D
    Names
    CG9277-PA
    CG9277-PB
    TUBULIN B-1 CHAIN
    b-tubulin56D
    beta tubulin
    beta-1 tubulin
    beta-1-tubulin
    beta-Tubulin
    beta-Tubulin 56D
    beta-Tubulin at 56 D
    beta-tubulin-56D
    beta1 tubulin
    beta1-Tubulin
    betaTub56D-PA
    betaTub56D-PB
    betatubulin
    lethal (2) k00705
    tubulin
    tubulin beta-1 chain
    tubulin beta1-chain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19447319..19451600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079071.3 → NP_523795.2  beta-Tubulin at 56D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523795.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24560, Q53YG6, Q9V8V4
      UniProtKB/TrEMBL
      E0R982
      Related
      FBpp0085720
      Conserved Domains (1) summary
      PLN00220
      Location:1 → 429
      PLN00220; tubulin beta chain; Provisional

    2. NM_166356.2 → NP_725896.1  beta-Tubulin at 56D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBL0, E0R982
      Related
      FBpp0085721
      Conserved Domains (2) summary
      PLN00220
      Location:29 → 438
      PLN00220; tubulin beta chain; Provisional
      cd02187
      Location:26 → 435
      beta_tubulin; The beta-tubulin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBL0 A1ZBL0
    Q24560.2 Q24560

    Gene LinkOut

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