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    CRMP Collapsin Response Mediator Protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CRMPprovided by FlyBase
    Official Full Name
    Collapsin Response Mediator Proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023023
    Locus tag
    Dmel_CG1411
    See related
    AllianceGenome:FB:FBgn0023023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:HL02693; CG1411; crmp; DHP; Dmel\CG1411; EP(3)3238; EP3238; l(3)83Ba; pyd2; Pyd2
    Summary
    Enables dihydropyrimidinase activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; Ras protein signal transduction; and centrosome localization. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic head sensory system; ganglia; larval central nervous system; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome; dihydropyrimidinase deficiency; and purine-pyrimidine metabolic disorder. Orthologous to several human genes including CRMP1 (collapsin response mediator protein 1); DPYSL3 (dihydropyrimidinase like 3); and DPYSL5 (dihydropyrimidinase like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See CRMP in Genome Data Viewer
    Location:
    83B2-83B2; 3-47.5 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5571108..5579189)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1396830..1404911)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ras homolog enriched in brain Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU4:25F-C137 Neighboring gene DNA polymerase zeta subunit 2 Neighboring gene noisette

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity. Stroedicke M, et al. Genome Res, 2015 May. PMID 25908449, Free PMC Article
    2. Dysregulated CRMP Mediates Circadian Deficits in a Drosophila Model of Fragile X Syndrome. Zhao J, et al. Neurosci Bull, 2021 Jul. PMID 33856646, Free PMC Article
    3. MICAL, the flavoenzyme participating in cytoskeleton dynamics. Vanoni MA, et al. Int J Mol Sci, 2013 Mar 27. PMID 23535333, Free PMC Article
    4. Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. Jegla T, et al. PLoS Genet, 2016 Dec. PMID 27911898, Free PMC Article
    5. Somatic sex-specific transcriptome differences in Drosophila revealed by whole transcriptome sequencing. Chang PL, et al. BMC Genomics, 2011 Jul 14. PMID 21756339, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.
      Title: Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.
    2. DHP and CRMP proteins are derived by different processes in flies and vertebrates, indicating that diverse genetic mechanisms have mediated the evolution of this protein family in animals.
      Title: Divergent functions through alternative splicing: the Drosophila CRMP gene in pyrimidine metabolism, brain, and behavior.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dihydropyrimidinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydropyrimidinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    collapsin response mediator protein
    Names
    CG1411-PA
    CG1411-PB
    CG1411-PE
    CRMP-PA
    CRMP-PB
    CRMP-PE
    collapsin response mediating protein
    collapsing response mediator protein
    dihydropyrimidinase
    dihydropyrimidine amidohydrolase
    NP_477307.1
    NP_730952.1
    NP_730954.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5571108..5579189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169070.2 → NP_730952.1  collapsin response mediator protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730952.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VND9
      Related
      FBpp0088627
      Conserved Domains (1) summary
      cl00281
      Location:22 → 331
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    2. NM_169072.3 → NP_730954.2  collapsin response mediator protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730954.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YE81, Q2XST3, Q86LT3, Q8IPQ2
      Conserved Domains (2) summary
      PRK09060
      Location:24 → 483
      PRK09060; dihydroorotase; Validated
      cd01314
      Location:22 → 475
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

    3. NM_057959.3 → NP_477307.1  collapsin response mediator protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477307.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YE81, Q2XST3, Q9V3N7
      Related
      FBpp0088628
      Conserved Domains (2) summary
      PRK09060
      Location:24 → 478
      PRK09060; dihydroorotase; Validated
      cd01314
      Location:22 → 470
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XST3 Q2XST3
    Q5U187 Q5U187
    Q8IPQ2 Q8IPQ2
    Q9V3N7 Q9V3N7
    Q9VND9 Q9VND9

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