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    CG15254 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG15254provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028949
    Locus tag
    Dmel_CG15254
    See related
    AllianceGenome:FB:FBgn0028949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BACcr44L22.2; BG:BACR44L22.2; Dmel\CG15254
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15254 in Genome Data Viewer
    Location:
    35D3-35D3; 2-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15613905..15614828, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15613905..15614828, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44865 Neighboring gene uncharacterized protein Neighboring gene Seminal metalloprotease-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila early ovarian transcriptome provides insight to the molecular causes of recombination rate variation across genomes. Adrian AB, et al. BMC Genomics, 2013 Nov 15. PMID 24228734, Free PMC Article
    2. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Jiao J, et al. Cell Rep, 2023 Jan 31. PMID 36640359, Free PMC Article
    3. Genie--gene finding in Drosophila melanogaster. Reese MG, et al. Genome Res, 2000 Apr. PMID 10779493, Free PMC Article
    4. Genetic changes accompanying the evolution of host specialization in Drosophila sechellia. Dworkin I, et al. Genetics, 2009 Feb. PMID 19033155, Free PMC Article
    5. Cross-species comparison of Drosophila male accessory gland protein genes. Mueller JL, et al. Genetics, 2005 Sep. PMID 15944345, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15254-PA
    CG15254-PB
    NP_001285959.1
    NP_609757.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15613905..15614828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299030.1 → NP_001285959.1  uncharacterized protein Dmel_CG15254, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3M3
      Conserved Domains (2) summary
      cd04280
      Location:61 → 248
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:58 → 251
      Astacin; Astacin (Peptidase family M12A)

    2. NM_135913.4 → NP_609757.1  uncharacterized protein Dmel_CG15254, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609757.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3M3
      Related
      FBpp0080341
      Conserved Domains (2) summary
      cd04280
      Location:61 → 248
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:58 → 251
      Astacin; Astacin (Peptidase family M12A)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3M3 Q9V3M3

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