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    4930503L19Rik RIKEN cDNA 4930503L19 gene [ Mus musculus (house mouse) ]

    Gene ID: 269033, updated on 27-Nov-2024

    Summary

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    Official Symbol
    4930503L19Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 4930503L19 geneprovided by MGI
    Primary source
    MGI:MGI:1922045
    See related
    Ensembl:ENSMUSG00000044906 AllianceGenome:MGI:1922045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lars; Las2; 9930107F24
    Summary
    Acts upstream of or within negative regulation of cell population proliferation. Predicted to be located in extracellular region. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human C18orf54 (chromosome 18 open reading frame 54). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 18.3), CNS E11.5 (RPKM 10.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See 4930503L19Rik in Genome Data Viewer
    Location:
    18 E2; 18 44.42 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (70585281..70605935, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (70452210..70472834, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44960 Neighboring gene dynactin associated protein like 1 Neighboring gene STARR-seq mESC enhancer starr_44961 Neighboring gene STARR-seq mESC enhancer starr_44962 Neighboring gene predicted gene, 31620 Neighboring gene STARR-positive B cell enhancer ABC_E11002 Neighboring gene StAR related lipid transfer domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E1519 Neighboring gene STARR-positive B cell enhancer ABC_E8725 Neighboring gene microRNA 6357 Neighboring gene polymerase (DNA directed), iota Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:70722848-70723181 Neighboring gene STARR-seq mESC enhancer starr_44965 Neighboring gene predicted gene, 31671 Neighboring gene methyl-CpG binding domain protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. Liu PY, et al. Cancer Res, 2009 Aug 1. PMID 19622765
    2. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lung adenoma susceptibility protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379430.1 → NP_001366359.1  lung adenoma susceptibility protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162297
      UniProtKB/TrEMBL
      G8CZ46
      Conserved Domains (2) summary
      pfam15044
      Location:437 → 497
      CLU_N; Mitochondrial function, CLU-N-term
      pfam15792
      Location:143 → 211
      LAS2; Lung adenoma susceptibility protein 2

    2. NM_001379431.1 → NP_001366360.1  lung adenoma susceptibility protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC162297
      UniProtKB/TrEMBL
      A0A1D5RMK7, G8CZ65
      Related
      ENSMUSP00000148818.2, ENSMUST00000212155.2
      Conserved Domains (1) summary
      pfam15792
      Location:161 → 229
      LAS2; Lung adenoma susceptibility protein 2

    3. NM_001379432.1 → NP_001366361.1  lung adenoma susceptibility protein 2 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC162297
      UniProtKB/TrEMBL
      G8CZ60
      Conserved Domains (1) summary
      pfam15792
      Location:161 → 229
      LAS2; Lung adenoma susceptibility protein 2

    4. NM_001379433.1 → NP_001366362.1  lung adenoma susceptibility protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC162297
      UniProtKB/TrEMBL
      G8CZ56, Q3UFM3
      Related
      ENSMUSP00000148553.2, ENSMUST00000212683.2
      Conserved Domains (1) summary
      pfam15792
      Location:161 → 229
      LAS2; Lung adenoma susceptibility protein 2

    5. NM_172967.2 → NP_766555.1  lung adenoma susceptibility protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_766555.1

      Status: VALIDATED

      Source sequence(s)
      AK037066
      Consensus CDS
      CCDS29333.1
      UniProtKB/Swiss-Prot
      Q8BNS5, Q8C2X0, Q8CB14
      UniProtKB/TrEMBL
      G8CZ46, G8CZ53
      Related
      ENSMUSP00000065118.4, ENSMUST00000067556.4
      Conserved Domains (1) summary
      pfam15792
      Location:161 → 229
      LAS2; Lung adenoma susceptibility protein 2

    RNA

    1. NR_166658.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC162297

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      70585281..70605935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250480.2 → XP_030106340.1  lung adenoma susceptibility protein 2 isoform X2

      UniProtKB/TrEMBL
      G8CZ60, G8CZ62
      Related
      ENSMUSP00000148769.2, ENSMUST00000212982.2
      Conserved Domains (1) summary
      pfam15792
      Location:161 → 229
      LAS2; Lung adenoma susceptibility protein 2

    2. XM_030250479.1 → XP_030106339.1  lung adenoma susceptibility protein 2 isoform X1

      UniProtKB/TrEMBL
      G8CZ60
      Conserved Domains (1) summary
      pfam15792
      Location:143 → 211
      LAS2; Lung adenoma susceptibility protein 2

    RNA

    1. XR_004939858.1 RNA Sequence

    2. XR_385993.5 RNA Sequence

    3. XR_385995.3 RNA Sequence

    4. XR_003952525.2 RNA Sequence

    5. XR_004939864.1 RNA Sequence

    6. XR_004939863.1 RNA Sequence

    7. XR_385996.5 RNA Sequence

    8. XR_004939859.1 RNA Sequence

    9. XR_003952524.2 RNA Sequence

    10. XR_004939862.1 RNA Sequence

    11. XR_004939861.1 RNA Sequence

    12. XR_004939860.1 RNA Sequence

      Related
      ENSMUST00000212539.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CB14.1 GenPept UniProtKB/Swiss-Prot:Q8CB14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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