Socs44A Suppressor of Cytokine Signaling at 44A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Socs44Aprovided by FlyBase
Official Full Name: Suppressor of Cytokine Signaling at 44Aprovided by FlyBase
Primary source: FLYBASE:FBgn0033266
Locus tag: Dmel_CG2160
See related: AllianceGenome:FB:FBgn0033266
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2160; Dmel\CG2160; dmSocs44A; SOCS; socs42A; socs44A; Socs44a; SOCS44A; Socs44E
Summary: Predicted to enable signaling adaptor activity. Involved in negative regulation of receptor signaling pathway via JAK-STAT and positive regulation of epidermal growth factor receptor signaling pathway. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval tracheal section; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal system cancer (multiple); malaria; obesity; and reproductive organ cancer (multiple). Orthologous to several human genes including CISH (cytokine inducible SH2 containing protein); SOCS1 (suppressor of cytokine signaling 1); and SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 44B3-44B3; 2-58 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8127575..8129476)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4015080..4016981)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: suppressor of cytokine signaling at 44A

Names: CG2160-PA; Socs44A-PA; suppressor of cytokine signaling at 44E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8127575..8129476

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078935.3 → NP_523659.1 suppressor of cytokine signaling at 44A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523659.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JVF1

Related

FBpp0087862

Conserved Domains (2) summary

cd09923
Location:188 → 266

SH2_SOCS_family; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) family

cl02533
Location:293 → 333

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...