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    Efa6 Exchange factor for Arf 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42665, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Efa6provided by FlyBase
    Official Full Name
    Exchange factor for Arf 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0051158
    Locus tag
    Dmel_CG31158
    See related
    AllianceGenome:FB:FBgn0051158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18185; CG31158; CG6941; dEfa6; Dmel\CG31158; dPsd; efa6; EFA6
    Summary
    Enables microtubule binding activity. Involved in several processes, including axoneme assembly; compound eye morphogenesis; and negative regulation of microtubule polymerization. Located in axon; cell body; and cell cortex. Colocalizes with adherens junction. Is expressed in adult head. Used to study alcohol use disorder. Orthologous to several human genes including PSD (pleckstrin and Sec7 domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Efa6 in Genome Data Viewer
    Location:
    94B5-94B6; 3-75 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22587755..22608842)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18413477..18434564)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene buttonless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosome recycling factor 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila. Liu X, et al. Cell Regen, 2023 Apr 2. PMID 37005942, Free PMC Article
    2. The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. Gonzalez DA, et al. Mol Psychiatry, 2018 Mar. PMID 28607459, Free PMC Article
    3. Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Casanova JE. Traffic, 2007 Nov. PMID 17850229
    4. Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex. Qu Y, et al. Elife, 2019 Nov 13. PMID 31718774, Free PMC Article
    5. Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Cox R, et al. Mol Biol Cell, 2004 Apr. PMID 14742722, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ARF protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to alcohol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exchange factor for Arf 6
    Names
    CG31158-PC
    CG31158-PD
    CG31158-PG
    CG31158-PH
    CG31158-PI
    Efa6 pleckstrin and Sec7 domain containing
    Efa6-PC
    Efa6-PD
    Efa6-PG
    Efa6-PH
    Efa6-PI
    exchange factor for Arf 6 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22587755..22608842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170027.4 → NP_732769.3  exchange factor for Arf 6, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732769.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QD55
      Conserved Domains (4) summary
      cd00171
      Location:910 → 1079
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd00992
      Location:7 → 85
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13295
      Location:1116 → 1238
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:1120 → 1231
      PH; PH domain

    2. NM_001170220.2 → NP_001163691.2  exchange factor for Arf 6, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163691.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JR81, A8JR82, A8WHG2, C0PUX2, E1JIT7, E2QD55, E2QD56, Q8MRV5
      Conserved Domains (4) summary
      PHA03269
      Location:225 → 344
      PHA03269; envelope glycoprotein C; Provisional
      cd00171
      Location:1124 → 1293
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd00992
      Location:7 → 85
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13295
      Location:1330 → 1452
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    3. NM_176541.3 → NP_788718.3  exchange factor for Arf 6, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788718.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QD56
      Conserved Domains (4) summary
      cd00171
      Location:1044 → 1213
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd00992
      Location:7 → 85
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13295
      Location:1250 → 1372
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:1254 → 1365
      PH; PH domain

    4. NM_001104404.2 → NP_001097874.1  exchange factor for Arf 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR81
      Conserved Domains (4) summary
      cd00171
      Location:1044 → 1213
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd00992
      Location:7 → 85
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13295
      Location:1250 → 1372
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:1254 → 1365
      PH; PH domain

    5. NM_001104403.2 → NP_001097873.1  exchange factor for Arf 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR82
      Conserved Domains (4) summary
      cd00171
      Location:910 → 1079
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd00992
      Location:7 → 85
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13295
      Location:1116 → 1238
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:1120 → 1231
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIT7.2 E1JIT7

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