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    cnk connector enhancer of ksr [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cnkprovided by FlyBase
    Official Full Name
    connector enhancer of ksrprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286070
    Locus tag
    Dmel_CG6556
    See related
    AllianceGenome:FB:FBgn0286070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.129; anon-WO0257455.27; CG6556; Cnk; CNK; Dmel\CG6556; EC2-3; EK2-3; l(2)k16314; sag
    Summary
    Enables MAP-kinase scaffold activity; enzyme regulator activity; and protein kinase binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; open tracheal system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including apical part of cell; cell cortex; and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to several human genes including CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cnk in Genome Data Viewer
    Location:
    54B7-54B7; 2-82 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17413970..17420007, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13301475..13307512, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vajk4 Neighboring gene Proteasome alpha5 subunit Neighboring gene lethal (2) k01209 Neighboring gene uncharacterized protein Neighboring gene Methylthioadenosine phosphorylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CNKSR1 gene defect can cause syndromic autosomal recessive intellectual disability. Kazeminasab S, et al. Am J Med Genet B Neuropsychiatr Genet, 2018 Dec. PMID 30450701
    2. The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor. Fritz RD, et al. Biochem Biophys Res Commun, 2005 Dec 30. PMID 16289034
    3. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Clapéron A, et al. Oncogene, 2007 May 14. PMID 17496912
    4. Ras/MAPK signaling mediates adipose tissue control of ovarian germline survival and ovulation in Drosophila melanogaster. Bradshaw T, et al. Dev Biol, 2024 Jun. PMID 38423203
    5. ERK signaling couples nutrient status to antiviral defense in the insect gut. Xu J, et al. Proc Natl Acad Sci U S A, 2013 Sep 10. PMID 23980175, Free PMC Article

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cnk and its binding partner Ave serve a critical components for Alk signaling in Drosophila
      Title: The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila.
    2. Review highlights the implication of CNK and KSR in a novel mechanism regulating RAS-mediated RAF activation.
      Title: KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
    3. the integration of RTK-induced RAS and Src42 signals by CNK as a two-component input is essential for RAF activation
      Title: Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables MAP-kinase scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction HGI PubMed 
    involved_in positive regulation of Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal region determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in torso signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tracheal outgrowth, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    connector enhancer of ksr
    Names
    CG6556-PA
    CG6556-PB
    cnk-PA
    cnk-PB
    connector enhancer of KSR
    enhancer of KDN
    semang

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17413970..17420007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299595.1 → NP_001286524.1  connector enhancer of ksr, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286524.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KNQ9
      Conserved Domains (6) summary
      cd09511
      Location:6 → 74
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:7 → 74
      SAM; Sterile alpha motif
      cd00992
      Location:206 → 283
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13326
      Location:720 → 810
      PH_CNK_insect-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:720 → 814
      PH; PH domain
      pfam10534
      Location:82 → 165
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

    2. NM_166223.2 → NP_725671.1  connector enhancer of ksr, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725671.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KNQ9
      Related
      FBpp0086117
      Conserved Domains (6) summary
      cd09511
      Location:6 → 74
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:7 → 74
      SAM; Sterile alpha motif
      cd00992
      Location:206 → 283
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13326
      Location:720 → 810
      PH_CNK_insect-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:720 → 814
      PH; PH domain
      pfam10534
      Location:82 → 165
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KNQ9 Q7KNQ9

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