alpha-Cat alpha Catenin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: alpha-Catprovided by FlyBase
Official Full Name: alpha Cateninprovided by FlyBase
Primary source: FLYBASE:FBgn0010215
Locus tag: Dmel_CG17947
See related: AllianceGenome:FB:FBgn0010215
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: a-cat; a-Cat; alpha-cat; alpha-CAT; alpha-catenin; alpha-ctn; alphacat; alphaCat; alphaCAT; alphaCatenin; CG17947; CT39986; D-alpha-catenin; Dalpha-cat; Dalpha-Cat; DalphaC; Dalphacat; Dmcatp; Dmel\CG17947; LD30423p
Summary: Predicted to enable actin filament binding activity and beta-catenin binding activity. Involved in several processes, including apical constriction; dorsal closure, amnioserosa morphology change; and head morphogenesis. Located in adherens junction and plasma membrane. Part of catenin complex. Is expressed in several structures, including adult neuromere; epithelium; gut section; imaginal disc; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13; complex cortical dysplasia with other brain malformations; and patterned macular dystrophy 2. Orthologous to several human genes including CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 80F1-80F2; 3-47 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (23318646..23338100, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (23311746..23331200, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that recruitment of Jub by alpha-catenin promotes Yki activity and Drosophila wing growth
Title: Recruitment of Jub by α-catenin promotes Yki activity and Drosophila wing growth.
our findings indicate that a-Cat acts through multiple mechanisms to control tissue growth, including regulation of AJ stability, mechanosensitive Ajuba recruitment, and dynamic direct F-actin interactions.
Title: Role of α-Catenin and its mechanosensing properties in regulating Hippo/YAP-dependent tissue growth.
alpha-Catenin controls actomyosin dynamics by stabilising and promoting the formation of actomyosin foci, and also stabilises DE-Cadherin (Drosophila E-Cadherin, also known as Shotgun) at the cell membrane, suggesting that medioapical actomyosin contractility regulates junction stability.
Title: α-Catenin stabilises Cadherin-Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction.
Increased Rap1 activity restricts epithelial invagination in an alpha-catenin-dependent manner.
Title: Distinct Rap1 activity states control the extent of epithelial invagination via α-catenin.
alpha-Cat mutant phenotype can be rescued by the expression of a DE-cadherin::alpha-Catenin fusion protein, which argues against an essential cytosolic, cadherin-independent role of Drosophila alpha-Catenin
Title: Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function.
alpha-catenin and p120(ctn) are key players in a mechanism of recruiting Rho1 to its sites of action.
Title: Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c23321125-23320611 mobile_element_type = transposon:INE-1{}4544
Loc: c23325172-23324617 mobile_element_type = transposon:INE-1{}4547
Loc: c23326428-23326112 mobile_element_type = transposon:INE-1{}4548
Loc: c23329827-23329420 mobile_element_type = transposon:INE-1{}4550
Loc: c23333817-23331664 mobile_element_type = transposon:Cr1a{}1161
Loc: c23334162-23331503 mobile_element_type = transposon:INE-1{}4559
Loc: c23335600-23335526 mobile_element_type = transposon:INE-1{}4560
Loc: c23335860-23335639 mobile_element_type = transposon:1360{}4102
Loc: c23336510-23335858 mobile_element_type = transposon:1360{}4100
Loc: c23336582-23336533 mobile_element_type = transposon:INE-1{}4562
Loc: c23337358-23336720 mobile_element_type = transposon:INE-1{}4098
Loc: c23337550-23337395 mobile_element_type = transposon:INE-1{}4566

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical constriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal closure, amnioserosa morphology change	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha catenin

Names: CG17947-PA; CG17947-PB; D-alpha-catenin; Dalpha-Catenin; Dalpha-cadherin; a-catenin; alpha-Cat-PA; alpha-Cat-PB; alpha-Catenin; alpha-Ctenin; alphaCatenin; dalphacatenin