msn misshapen [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: msnprovided by FlyBase
Official Full Name: misshapenprovided by FlyBase
Primary source: FLYBASE:FBgn0010909
Locus tag: Dmel_CG16973
See related: AllianceGenome:FB:FBgn0010909
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 6286; CG16973; Dmel\CG16973; DMSN; HGK; JNKKKK; l(3)03349; l(3)06946; l(3)6286; l(3)j1E2; MESR5; msm; Msn; MSN; Nik; NIK
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including imaginal disc fusion, thorax closure; regulation of signal transduction; and tumor necrosis factor-mediated signaling pathway. Located in cell cortex and cytosol. Colocalizes with contractile ring. Is expressed in several structures, including adult brain; adult central complex; adult head; adult optic lobe; and cortical zone of lymph gland primary lobe. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to several human genes including TNIK (TRAF2 and NCK interacting kinase) and MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 62E6-62E7; 3-3 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (2554847..2586540, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (2554847..2586540, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Misshapen Disruption Cooperates with Ras(V12) to Drive Tumorigenesis.
Title: Misshapen Disruption Cooperates with Ras(V12) to Drive Tumorigenesis.
Results indicate that misshapen (msn) is a key regulator of ovary border cells (BC) migration.
Title: Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration.
the Misshapen-Warts-Yorkie pathway acts in enteroblasts to control niche signaling to intestinal stem cells
Title: The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila.
Misshapen's conserved role in cell migration and suggest that follicle cell planar polarity may be an emergent property of individual cell migratory behaviors within the epithelium.
Title: Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila.
Targeted expression of an active form of Msn in the wing imaginal disk disrupted activation of endogenous MAD by Dpp and expression of the Dpp/MAD target gene.
Title: Smad inhibition by the Ste20 kinase Misshapen.
The msn gene functions to modulate the levels and/or distribution of Drosophila E-cadherin to promote the invasive migratory behaviour of border cells.
Title: The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila.
the lamellocyte-active enhancer in th misshapen gene likely serves as a transcriptional target within a genetic auto-regulatory circuit that promotes the production of lamellocytes in immune-challenged or genetically-compromised animals
Title: Characterization of a lamellocyte transcriptional enhancer located within the misshapen gene of Drosophila melanogaster.
we show that Misshapen (Msn), the fly homolog of the vertebrate Nck-interacting kinase is a component of a novel signaling pathway that regulates photoreceptor (R-cell) nuclear migration in the developing Drosophila compound eye.
Title: The Ste20-like kinase misshapen functions together with Bicaudal-D and dynein in driving nuclear migration in the developing drosophila eye.
Data suggest that Bifocal functions downstream of Misshapen to reorganize actin cytoskeleton in decelerating R cell growth cone motility at the target region.
Title: Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0675 (e-PCR)
- UniSTS:18737

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase kinase activity	TAS Traceable Author Statement more info	PubMed
enables MAP kinase kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insect visual primordium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IEP Inferred from Expression Pattern more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with contractile ring	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: misshapen

Names: CG16973-PA; CG16973-PB; CG16973-PC; CG16973-PD; CG16973-PF; CG16973-PG; CG16973-PH; CG16973-PI; NIK; mishappen; msn-PA; msn-PB; msn-PC; msn-PD; msn-PF; msn-PG; msn-PH; msn-PI

NP_001261331.1

EC 2.7.11.1

NP_001261332.1

EC 2.7.11.1

NP_001261333.1

EC 2.7.11.1

NP_524679.3

EC 2.7.11.1

NP_995971.2

EC 2.7.11.1

NP_995972.1

EC 2.7.11.1

NP_995973.1

EC 2.7.11.1

NP_995974.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

2554847..2586540 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206251.3 → NP_995973.1 misshapen, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995973.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KV88, Q7M3J7

Conserved Domains (3) summary

smart00036
Location:781 → 1082

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:32 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:25 → 296

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_206252.3 → NP_995974.1 misshapen, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995974.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KV90, Q7M3J7

Conserved Domains (3) summary

smart00036
Location:879 → 1180

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:32 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:25 → 296

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_079940.5 → NP_524679.3 misshapen, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524679.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9W002

Related

FBpp0072830

Conserved Domains (3) summary

smart00036
Location:1183 → 1484

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:32 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:25 → 296

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_001274404.1 → NP_001261333.1 misshapen, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261333.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KV90, Q7M3J7

Conserved Domains (3) summary

smart00036
Location:879 → 1180

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:32 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:25 → 296

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_206250.3 → NP_995972.1 misshapen, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995972.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KV88, Q7M3J7

Conserved Domains (3) summary

smart00036
Location:781 → 1082

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:32 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:25 → 296

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_001274403.1 → NP_001261332.1 misshapen, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261332.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBJ7, Q7M3J7

Conserved Domains (3) summary

smart00036
Location:892 → 1193

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:32 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:25 → 296

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_206249.3 → NP_995971.2 misshapen, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995971.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KV89, Q7M3J7

Conserved Domains (3) summary

smart00036
Location:780 → 1081

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:32 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:25 → 296

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_001274402.1 → NP_001261331.1 misshapen, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261331.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH19

Conserved Domains (3) summary

smart00036
Location:1085 → 1384

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:32 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:25 → 296

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases