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    syd sunday driver [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sydprovided by FlyBase
    Official Full Name
    sunday driverprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024187
    Locus tag
    Dmel_CG8110
    See related
    AllianceGenome:FB:FBgn0024187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8110; Dmel\CG8110; dsyd-1; JIP-3; jip3; Syd
    Summary
    Enables kinesin binding activity and signaling receptor complex adaptor activity. Involved in several processes, including axo-dendritic transport; protein stabilization; and synapse assembly. Located in trans-Golgi network transport vesicle. Is active in presynaptic cytosol. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and liver cirrhosis. Orthologous to several human genes including MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See syd in Genome Data Viewer
    Location:
    66A20-66A20; 3-21 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7916650..7936120, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7909750..7929220, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32368 Neighboring gene uncharacterized protein Neighboring gene Transmembrane protein 43 Neighboring gene Signal recognition particle 9 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transduction. When worlds collide--trafficking in JNK. Goldstein LS. Science, 2001 Mar 16. PMID 11256408
    2. Linkers, packages and pathways: new concepts in axonal transport. Almenar-Queralt A, et al. Curr Opin Neurobiol, 2001 Oct. PMID 11595487
    3. Kinesin delivers: identifying receptors for motor proteins. Hollenbeck PJ. J Cell Biol, 2001 Mar 5. PMID 11238467, Free PMC Article
    4. Kinesin molecular motors: transport pathways, receptors, and human disease. Goldstein LS. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11416178, Free PMC Article
    5. Kinesin transport: driving kinesin in the neuron. Hays T, et al. Curr Biol, 2001 Feb 20. PMID 11250168

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP.
      Title: Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP.
    2. Syd/JIP3 is a novel regulator of myogenesis that is required for proper intracellular organization and tissue function.
      Title: Syd/JIP3 and JNK signaling are required for myonuclear positioning and muscle function.
    3. the primary function of Syd-1 in R7 photoreceptors may be to promote Trio activity.
      Title: Loss of syd-1 from R7 neurons disrupts two distinct phases of presynaptic development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables JUN kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP-kinase scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP-kinase scaffold activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP-kinase scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor complex adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synapse assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sunday driver
    Names
    CG8110-PA
    CG8110-PB
    CG8110-PC
    CG8110-PD
    CG8110-PE
    CG8110-PF
    CG8110-PG
    CG8110-PH
    CG8110-PI
    CG8110-PJ
    CG8110-PK
    syd-PA
    syd-PB
    syd-PC
    syd-PD
    syd-PE
    syd-PF
    syd-PG
    syd-PH
    syd-PI
    syd-PJ
    syd-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7916650..7936120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300046.1 → NP_001286975.1  sunday driver, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286975.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEX9
      Conserved Domains (3) summary
      pfam04100
      Location:361 → 511
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:36 → 189
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:349 → 417
      JIP_LZII; JNK-interacting protein leucine zipper II

    2. NM_001274620.1 → NP_001261549.1  sunday driver, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEX9
      Conserved Domains (3) summary
      pfam04100
      Location:361 → 511
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:36 → 189
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:349 → 417
      JIP_LZII; JNK-interacting protein leucine zipper II

    3. NM_001274619.1 → NP_001261548.1  sunday driver, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEG9
      Conserved Domains (3) summary
      pfam04100
      Location:361 → 511
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:36 → 189
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:349 → 417
      JIP_LZII; JNK-interacting protein leucine zipper II

    4. NM_001274621.1 → NP_001261550.1  sunday driver, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEQ0
      Conserved Domains (3) summary
      pfam04100
      Location:361 → 511
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:36 → 189
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:349 → 417
      JIP_LZII; JNK-interacting protein leucine zipper II

    5. NM_001274623.1 → NP_001261552.1  sunday driver, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261552.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBV5
      Conserved Domains (3) summary
      pfam04100
      Location:367 → 517
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:36 → 189
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:355 → 423
      JIP_LZII; JNK-interacting protein leucine zipper II

    6. NM_001274622.1 → NP_001261551.1  sunday driver, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHR0
      Conserved Domains (3) summary
      pfam04100
      Location:367 → 517
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:36 → 189
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:355 → 423
      JIP_LZII; JNK-interacting protein leucine zipper II

    7. NM_001274624.1 → NP_001261553.1  sunday driver, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEH2
      Conserved Domains (3) summary
      pfam04100
      Location:367 → 517
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:36 → 189
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:355 → 423
      JIP_LZII; JNK-interacting protein leucine zipper II

    8. NM_001169902.2 → NP_001163373.1  sunday driver, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI66
      Conserved Domains (3) summary
      pfam04100
      Location:374 → 524
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:43 → 196
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:362 → 430
      JIP_LZII; JNK-interacting protein leucine zipper II

    9. NM_001169903.1 → NP_001163374.1  sunday driver, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163374.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI64
      Conserved Domains (3) summary
      pfam04100
      Location:335 → 485
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:10 → 163
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:323 → 391
      JIP_LZII; JNK-interacting protein leucine zipper II

    10. NM_168245.3 → NP_729311.2  sunday driver, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729311.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GQF1
      Related
      FBpp0076484
      Conserved Domains (3) summary
      pfam04100
      Location:341 → 491
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:10 → 163
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:329 → 397
      JIP_LZII; JNK-interacting protein leucine zipper II

    11. NM_079913.3 → NP_524652.1  sunday driver, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524652.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5U182, Q8IGL6, Q95SK0, Q9GQF1, Q9VSC0
      Related
      FBpp0076483
      Conserved Domains (3) summary
      pfam04100
      Location:374 → 524
      Vps53_N; Vps53-like, N-terminal
      pfam09744
      Location:43 → 196
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:362 → 430
      JIP_LZII; JNK-interacting protein leucine zipper II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JI64 E1JI64
    E1JI66 E1JI66
    M9PBV5 M9PBV5
    M9PEG9 M9PEG9
    M9PEH2 M9PEH2
    M9PEQ0 M9PEQ0
    M9PEX9 M9PEX9
    M9PHR0 M9PHR0
    Q9GQF1.1 Q9GQF1

    Gene LinkOut

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