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    GluRIID Glutamate receptor IID [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44483, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GluRIIDprovided by FlyBase
    Official Full Name
    Glutamate receptor IIDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028422
    Locus tag
    Dmel_CG18039
    See related
    AllianceGenome:FB:FBgn0028422
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    brec; CG18039; CT13538; DGluRIID; DKaiR-IA; DmelGluRIID; Dmel\CG18039; GluR-IID; GluRIA; gluRIID; Kai-RIA; kaiRIA; KaiRIA
    Summary
    Enables glutamate-gated calcium ion channel activity. Involved in calcium ion transport; neuromuscular synaptic transmission; and rhythmic excitation. Located in muscle cell postsynaptic specialization. Part of ionotropic glutamate receptor complex. Is expressed in several structures, including adult head; cardioblast; embryonic/larval neuromuscular junction; somatic muscle cell; and somatic muscle primordium. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GluRIID in Genome Data Viewer
    Location:
    92F4-92F4; 3-69 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20648595..20652450, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16474317..16478172, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 3-kinase 92E Neighboring gene Leucine-rich repeat kinase Neighboring gene Glutamate receptor IIE Neighboring gene Neprilysin 4 Neighboring gene Cuticular protein 92F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Naked dense bodies provoke depression. Hallermann S, et al. J Neurosci, 2010 Oct 27. PMID 20980589, Free PMC Article
    2. Rapid active zone remodeling during synaptic plasticity. Weyhersmüller A, et al. J Neurosci, 2011 Apr 20. PMID 21508229, Free PMC Article
    3. Hebbian plasticity guides maturation of glutamate receptor fields in vivo. Ljaschenko D, et al. Cell Rep, 2013 May 30. PMID 23643532
    4. RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Liu KS, et al. Science, 2011 Dec 16. PMID 22174254
    5. The 4.1 protein coracle mediates subunit-selective anchoring of Drosophila glutamate receptors to the postsynaptic actin cytoskeleton. Chen K, et al. J Neurosci, 2005 Jul 13. PMID 16014728, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-gated calcium ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-gated receptor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables glutamate-gated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kainate selective glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhythmic excitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, glutamatergic IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ionotropic glutamate receptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in muscle cell postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor IID
    Names
    CG18039-PA
    GluRIID-PA
    KaiRIA
    bad reception

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20648595..20652450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143725.3 → NP_651982.1  glutamate receptor IID [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58CK5, Q9I7I5, Q9TVI0
      Related
      FBpp0083346
      Conserved Domains (4) summary
      cd06382
      Location:35 → 397
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:417 → 788
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:549 → 819
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:46 → 380
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TVI0 Q9TVI0

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