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    PIG-Wb Phosphatidylinositol glycan anchor biosynthesis class W b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Wbprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class W bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035265
    Locus tag
    Dmel_CG18173
    See related
    AllianceGenome:FB:FBgn0035265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18173; Dmel\CG18173; PIG-W; PIGWb
    Summary
    Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in membrane. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-Wb in Genome Data Viewer
    Location:
    62B1-62B1; 3-1.0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1735853..1738106, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1735853..1738106, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene draper Neighboring gene uncharacterized protein Neighboring gene Outer segment 4 Neighboring gene Glycerol kinase 2 Neighboring gene uncharacterized protein Neighboring gene Chitinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol. Akimana C, et al. PLoS One, 2010 Jun 11. PMID 20552012, Free PMC Article
    2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    3. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    4. The genetics of egg retention and fertilization success in Drosophila: One step closer to understanding the transition from facultative to obligate viviparity. Horváth B, et al. Evolution, 2018 Feb. PMID 29265369
    5. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class W b
    Names
    CG18173-PA
    CG18173-PB
    PIG-Wb-PA
    PIG-Wb-PB
    NP_001261279.1
    NP_647654.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1735853..1738106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274350.1 → NP_001261279.1  phosphatidylinositol glycan anchor biosynthesis class W b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261279.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W096
      Conserved Domains (1) summary
      cl02109
      Location:85 → 503
      GWT1; GWT1

    2. NM_139397.3 → NP_647654.1  phosphatidylinositol glycan anchor biosynthesis class W b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W096
      Related
      FBpp0072678
      Conserved Domains (1) summary
      cl02109
      Location:85 → 503
      GWT1; GWT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W096 Q9W096

    Gene LinkOut

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