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    Hmt4-20 Histone methyltransferase 4-20 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31015, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hmt4-20provided by FlyBase
    Official Full Name
    Histone methyltransferase 4-20provided by FlyBase
    Primary source
    FLYBASE:FBgn0025639
    Locus tag
    Dmel_CG13363
    See related
    AllianceGenome:FB:FBgn0025639
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD36415; CG13363; Dmel\CG13363; dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20; SUV4-20; Suv4.20
    Summary
    Enables histone H4K20 trimethyltransferase activity and histone H4K20me methyltransferase activity. Involved in constitutive heterochromatin formation and retrotransposon silencing by heterochromatin formation. Located in heterochromatin and nucleus. Is expressed in organism. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 51. Orthologous to several human genes including KMT5B (lysine methyltransferase 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hmt4-20 in Genome Data Viewer
    Location:
    1B13-1B14; 1-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (648483..656033, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (542516..550066, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Regulator of cullins 1a Neighboring gene SKP1-related A Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The histone H4 lysine 20 monomethyl mark, set by PR-Set7 and stabilized by L(3)mbt, is necessary for proper interphase chromatin organization. Sakaguchi A, et al. PLoS One, 2012. PMID 23024815, Free PMC Article
    2. Preferential dimethylation of histone H4 lysine 20 by Suv4-20. Yang H, et al. J Biol Chem, 2008 May 2. PMID 18296440, Free PMC Article
    3. The SET-domain protein superfamily: protein lysine methyltransferases. Dillon SC, et al. Genome Biol, 2005. PMID 16086857, Free PMC Article
    4. Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets. Dobson AJ, et al. Cell Rep, 2017 Jan 10. PMID 28076775, Free PMC Article
    5. Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading. Hines KA, et al. Genetics, 2009 Aug. PMID 19487560, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H4K20 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K20 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K20 trimethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K20 trimethyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H4K20me methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in constitutive heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transposable element silencing by heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone methyltransferase 4-20
    Names
    CG13363-PA
    CG13363-PB
    Hmt4-20-PA
    Hmt4-20-PB
    Suv4-20
    NP_001245453.1
    NP_569853.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      648483..656033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130497.4 → NP_569853.1  histone methyltransferase 4-20, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77261, Q8T029, Q8T3U6, Q9W5E0
      UniProtKB/TrEMBL
      H1UUR4, M9NE25
      Related
      FBpp0070146
      Conserved Domains (1) summary
      smart00317
      Location:256 → 372
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    2. NM_001258524.1 → NP_001245453.1  histone methyltransferase 4-20, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77261, Q8T029, Q8T3U6, Q9W5E0
      UniProtKB/TrEMBL
      H1UUR4, M9NE25
      Conserved Domains (1) summary
      smart00317
      Location:256 → 372
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NE25 M9NE25
    Q9W5E0.1 Q9W5E0

    Gene LinkOut

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