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    sgl sugarless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sglprovided by FlyBase
    Official Full Name
    sugarlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261445
    Locus tag
    Dmel_CG10072
    See related
    AllianceGenome:FB:FBgn0261445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    8310; BG01214; CG10072; Dmel\CG10072; kiwi; l(3)05007; l(3)08310; l(3)10503; l(3)65CEd; l(3)SG9; Sgl; ska; sl; UDP-GlcDH; UDPGDH; XIII
    Summary
    Enables UDP-glucose 6-dehydrogenase activity. Involved in several processes, including UDP-glucuronate biosynthetic process; epithelial cell migration, open tracheal system; and proteoglycan biosynthetic process. Acts upstream of with a positive effect on fibroblast growth factor receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval hemocyte; embryonic/larval midgut cell; epithelial furrow; gut section; and mesoderm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sgl in Genome Data Viewer
    Location:
    65D4-65D5; 3-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6959554..6964758, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6952654..6957858, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene Surfeit 1 Neighboring gene uncharacterized protein Neighboring gene Mis12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo hyaluronan synthesis upon expression of the mammalian hyaluronan synthase gene in Drosophila. Takeo S, et al. J Biol Chem, 2004 Apr 30. PMID 14966127
    2. Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes. Toyoda H, et al. J Biol Chem, 2000 Jul 21. PMID 10806213
    3. The never-ending story of peptide O-xylosyltransferase. Wilson IB. Cell Mol Life Sci, 2004 Apr. PMID 15095004, Free PMC Article
    4. Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling. Binari RC, et al. Development, 1997 Jul. PMID 9217004
    5. Regulated diversity of heparan sulfate. Lindahl U, et al. J Biol Chem, 1998 Sep 25. PMID 9737951

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 6-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 6-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 6-dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-glucuronate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-glucuronate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_positive_effect fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosaminoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sugarless
    Names
    CG10072-PA
    UDP-glucose 6-dehydrogenase
    UDP-glucose dehydrogenase
    distal W5.4 group XIII
    kiwi
    lethal(3)SG9
    sgl-PA
    suppenkasper
    NP_476980.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6959554..6964758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057632.4 → NP_476980.1  sugarless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02373, O02647, Q9VRZ9
      Related
      FBpp0076647
      Conserved Domains (1) summary
      PLN02353
      Location:1 → 459
      PLN02353; probable UDP-glucose 6-dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02373.1 O02373
    Q95SJ7 Q95SJ7

    Gene LinkOut

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