Ilp2 Insulin-like peptide 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ilp2provided by FlyBase
Official Full Name: Insulin-like peptide 2provided by FlyBase
Primary source: FLYBASE:FBgn0036046
Locus tag: Dmel_CG8167
See related: AllianceGenome:FB:FBgn0036046
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Akh; CG8167; dilp; Dilp; DILP; dilp 2; Dilp 2; DILP 2; dilp-2; dILP-2; Dilp-2; DILP-2; Dilp1-5; dilp2; dIlp2; dILP2; Dilp2; DILP2; DILPs; dipl2; dlp; Dmel\CG8167; Ilp; Ilp-2; ILP-2; ilp2; IlP2; ILP2; ILPs; IRP; llp2
Summary: Enables insulin receptor binding activity and receptor ligand activity. Involved in several processes, including determination of adult lifespan; germ-line stem-cell niche homeostasis; and insulin receptor signaling pathway. Is active in extracellular space. Is expressed in several structures, including adult gnathal ganglion; adult median bundle; brain; neurosecretory cell of pars intercerebralis; and pars intercerebralis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67C8-67C8; 3-31 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9799698..9800440)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9792798..9793540)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Independent insulin signaling modulators govern hot avoidance under different feeding states.
Title: Independent insulin signaling modulators govern hot avoidance under different feeding states.
Examination of Niddm20 candidate genes of OLETF rats in Drosophila melanogaster using inducible GeneSwitch GAL4 system.
Title: Examination of Niddm20 candidate genes of OLETF rats in Drosophila melanogaster using inducible GeneSwitch GAL4 system.
required for PI3-kinase activation and growth coordination between neuroblasts and glia in the brain
Title: Dilp-2-mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche.
Increasing miR-7 alters body growth and metabolism in an insulin-like-peptide-dependent manner, elevating circulating sugars and total body triglycerides, while decreasing animal growth.
Title: MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides.
Immunosenescence in Drosophila suggests its possible mechanisms that involve changes in insulin/IGF-1 signaling. (Review)
Title: Unraveling the Molecular Mechanism of Immunosenescence in Drosophila.
Using two long-lived IIS models, namely Drosophila lacking three insulin-like peptides (dilp2-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms
Title: Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice.
dPKD mediated secretion of dILP2 from neurosecretory cells during development is necessary for normal larval growth.
Title: Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide.
Results found that virgin females with knockout mutations of Ilp2, Ilp3 and Ilp5 show high mating success rate with higher locomotion.
Title: Knockout mutations of insulin-like peptide genes enhance sexual receptivity in Drosophila virgin females.
Knockdown of the Drosophila orthologues of human T2DM risk genes, including GLIS3 and BCL11A, revealed roles of these Drosophila genes in Ilp2 production or secretion.
Title: A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion.
Under hypoxic conditions, Sima nuclear localization in the fat body is associated with lipid droplet aggregation and impaired lipid mobilization to oenocytes. The fat body in turn, perhaps through a secreted signal, inhibits Dilp2 secretion from the larval brain, associated with reduced insulin receptor signaling in peripheral tissues.
Title: Insulin- and warts-dependent regulation of tracheal plasticity modulates systemic larval growth during hypoxia in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	IGI Inferred from Genetic Interaction more info	PubMed
enables insulin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of entry into reproductive diapause	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycogen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amino acid starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Insulin-like peptide 2

Names: CG8167-PA; Dilp2; Ilp2-PA; Insulin- related peptide 2; Insulin-like peptide; Insulin-related peptide; drosophila insulin like peptide 2; drosophila insulin-like peptide 2; drosophila insulin-like receptor; insulin-like 2; insulin-like peptide-2; insulin/insulin-like growth factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9799698..9800440

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079288.3 → NP_524012.1 Insulin-like peptide 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524012.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VT51

UniProtKB/TrEMBL

E7BBS1

Related

FBpp0076058

Conserved Domains (1) summary

cd04366
Location:111 → 132

IlGF_insulin_bombyxin_like; IlGF_like family, insulin_bombyxin_like subgroup. Members include a number of peptides including insulin, insulin-like growth factors I and II, insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related ...