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    CG30345 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246553, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG30345provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050345
    Locus tag
    Dmel_CG30345
    See related
    AllianceGenome:FB:FBgn0050345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG30345
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG30345 in Genome Data Viewer
    Location:
    45A13-45A13; 2-60 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9148689..9151892)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5036194..5039397)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 38 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44283

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Iron homeostasis in insects: Insights from Drosophila studies. Tang X, et al. IUBMB Life, 2013 Oct. PMID 24078394
    2. SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. Paik D, et al. J Immunol, 2017 Jul 1. PMID 28539433, Free PMC Article
    3. Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila. Rech GE, et al. PLoS Genet, 2019 Feb. PMID 30753202, Free PMC Article
    4. Iron absorption in Drosophila melanogaster. Mandilaras K, et al. Nutrients, 2013 May 17. PMID 23686013, Free PMC Article
    5. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30345-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9148689..9151892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165656.3 → NP_724760.2  uncharacterized protein Dmel_CG30345 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724760.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7R4, Q1EC10
      Conserved Domains (2) summary
      cd06174
      Location:121 → 472
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:102 → 437
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1EC10 Q1EC10

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