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    LRP1 LDL receptor protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35799, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LRP1provided by FlyBase
    Official Full Name
    LDL receptor protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0053087
    Locus tag
    Dmel_CG33087
    See related
    AllianceGenome:FB:FBgn0053087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30368; CG33087; CG8706; CT9297; Dm CG33087; Dmel\CG33087; dmLRP1; LRP-1; lrp1; Lrp1
    Summary
    Predicted to enable low-density lipoprotein particle receptor activity. Involved in regulation of axon guidance. Located in dendrite. Is expressed in adult brain cell body rind; adult head; and spermatozoon. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); keratosis pilaris atrophicans; lung disease (multiple); myocardial infarction; and sciatic neuropathy. Orthologous to several human genes including LRP1B (LDL receptor related protein 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LRP1 in Genome Data Viewer
    Location:
    44B8-44C2; 2-58 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8174165..8226438)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4061670..4113943)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene gasz Neighboring gene uncharacterized protein Neighboring gene Mlh1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44275 Neighboring gene uncharacterized protein Neighboring gene stable intronic sequence RNA 4 Neighboring gene deadpan

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport. Zhang JM, et al. J Mol Neurosci, 2022 Aug. PMID 35668313
    2. Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier. Li F, et al. Elife, 2023 May 4. PMID 37140181, Free PMC Article
    3. Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis. Vialat M, et al. Cancers (Basel), 2024 Jun 6. PMID 38893271, Free PMC Article
    4. A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila. Singh A, et al. Nat Commun, 2024 May 23. PMID 38782979, Free PMC Article
    5. Genomic and Transcriptomic Associations Identify a New Insecticide Resistance Phenotype for the Selective Sweep at the Cyp6g1 Locus of Drosophila melanogaster. Battlay P, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317781, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables low-density lipoprotein particle receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of lipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LDL receptor protein 1
    Names
    CG33087-PF
    CG33087-PG
    LDL receptor protein
    LDL receptor-related protein 1
    LDL-receptor-related protein 1
    LRP1-PF
    LRP1-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8174165..8226438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273871.2 → NP_001260800.2  LDL receptor protein 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260800.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFD1
      Conserved Domains (9) summary
      smart00192
      Location:3776 → 3808
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:2475 → 2517
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:3103 → 3141
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:4415 → 4450
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00112
      Location:2810 → 2844
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:2082 → 2120
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:449 → 487
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:1289 → 1317
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:2082 → 2152
      NHL; NHL repeat unit of beta-propeller proteins

    2. NM_176104.3 → NP_788284.3  LDL receptor protein 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788284.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7C4
      Conserved Domains (9) summary
      smart00192
      Location:3750 → 3782
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:2449 → 2491
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:3077 → 3115
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:4389 → 4424
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00112
      Location:2784 → 2818
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:2056 → 2094
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:423 → 461
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:1263 → 1291
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:2056 → 2126
      NHL; NHL repeat unit of beta-propeller proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFD1 A0A0B4KFD1
    A1Z7C4 A1Z7C4

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