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    Yeti yeti [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 7354404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Yetiprovided by FlyBase
    Official Full Name
    yetiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267398
    Locus tag
    Dmel_CG40218
    See related
    AllianceGenome:FB:FBgn0267398
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    41Aa; BcDNA:RE36623; BCNT; BEST:GH01620; CG40218; Dmel\CG40218; GroupI; l(2)41Aa; l(2)EMS31; l(2R)B; l(2R)EMS-31; SWC5; yeti; YETI
    Summary
    Enables kinesin binding activity. Involved in meiotic chromosome condensation and mitotic chromosome condensation. Located in nucleus and polytene chromosome. Is expressed in ovary. Orthologous to human CFDP1 (craniofacial development protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Yeti in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1343403..1345119, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (470036..471752, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44042 Neighboring gene lethal (2) 41Ab Neighboring gene long non-coding RNA:CR44043

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Bucentaur (BCNT) protein family: a long-neglected class of essential proteins required for chromatin/chromosome organization and function. Messina G, et al. Chromosoma, 2015 Jun. PMID 25547403
    2. On the evolution of Yeti, a Drosophila melanogaster heterochromatin gene. Moschetti R, et al. PLoS One, 2014. PMID 25405891, Free PMC Article
    3. The True Story of Yeti, the "Abominable" Heterochromatic Gene of Drosophila melanogaster. Prozzillo Y, et al. Front Physiol, 2019. PMID 31507454, Free PMC Article
    4. The Drosophila kinesin-I associated protein YETI binds both kinesin subunits. Wisniewski TP, et al. Biol Cell, 2003 Dec. PMID 14720462
    5. Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus. Messina G, et al. BMC Biol, 2022 Aug 3. PMID 35922843, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kinesin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    yeti
    Names
    CG40218-PA
    CG40218-PB
    Yeti-PA
    Yeti-PB
    lethal (2) 41Aa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      1343403..1345119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300707.1 → NP_001287636.1  yeti, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXI2
      Conserved Domains (1) summary
      pfam07572
      Location:165 → 237
      BCNT; Bucentaur or craniofacial development

    2. NM_001144065.2 → NP_001137537.1  yeti, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137537.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXI2
      Conserved Domains (1) summary
      pfam07572
      Location:165 → 237
      BCNT; Bucentaur or craniofacial development
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXI2 Q8SXI2

    Gene LinkOut

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