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    CG8586 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8586provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033320
    Locus tag
    Dmel_CG8586
    See related
    AllianceGenome:FB:FBgn0033320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SPH58; cSPH58; Dmel\CG8586; SPH58
    Summary
    Predicted to be involved in proteolysis. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8586 in Genome Data Viewer
    Location:
    44E2-44E2; 2-59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8692796..8696245, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4580301..4583750, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Acyl-CoA synthetase long-chain Neighboring gene transfer RNA:Leucine-CAG 1-1 Neighboring gene uncharacterized protein Neighboring gene Jonah 44E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary rate covariation identifies new members of a protein network required for Drosophila melanogaster female post-mating responses. Findlay GD, et al. PLoS Genet, 2014 Jan. PMID 24453993, Free PMC Article
    2. Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation. Veillard F, et al. Biochimie, 2016 Mar. PMID 26453810
    3. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469
    4. Transcriptional signature of an adult brain tumor in Drosophila. Loop T, et al. BMC Genomics, 2004 Apr 16. PMID 15090076, Free PMC Article
    5. Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Waterhouse RM, et al. Science, 2007 Jun 22. PMID 17588928, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8586-PA
    CG8586-PB
    CG8586-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8692796..8696245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299276.1 → NP_001286205.1  uncharacterized protein Dmel_CG8586, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7H7
      Conserved Domains (2) summary
      smart00020
      Location:197 → 430
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:197 → 433
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001299275.1 → NP_001286204.1  uncharacterized protein Dmel_CG8586, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7H7
      Conserved Domains (2) summary
      smart00020
      Location:197 → 430
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:197 → 433
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_136558.3 → NP_610402.1  uncharacterized protein Dmel_CG8586, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610402.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7H7
      Related
      FBpp0087804
      Conserved Domains (2) summary
      smart00020
      Location:197 → 430
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:197 → 433
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7H7 A1Z7H7
    Q8MSK6 Q8MSK6

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