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    Toll-6 Toll-6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Toll-6provided by FlyBase
    Official Full Name
    Toll-6provided by FlyBase
    Primary source
    FLYBASE:FBgn0036494
    Locus tag
    Dmel_CG7250
    See related
    AllianceGenome:FB:FBgn0036494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    18w-like; CG7250; CT22359; Dmel\CG7250; dTLR6; dToll6; Tl-6; toll; Toll; Toll 6; TOLL 6; toll-6; Toll6
    Summary
    Enables neurotrophin receptor activity. Involved in several processes, including axis elongation; convergent extension; and dendrite guidance. Predicted to be located in membrane. Is expressed in several structures, including adult olfactory antennal lobe glomerulus; anlage in statu nascendi; brain; head epidermis primordium; and motor neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Toll-6 in Genome Data Viewer
    Location:
    71C2-71C2; 3-43 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15336692..15344315)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15329792..15337415)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43247 Neighboring gene long non-coding RNA:CR43992 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43625

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct expression patterns detected within individual tissues by the GAL4 enhancer trap technique. Gustafson K, et al. Genome, 1996 Feb. PMID 8851804
    2. Electrophysiological correlates of rest and activity in Drosophila melanogaster. Nitz DA, et al. Curr Biol, 2002 Nov 19. PMID 12445387
    3. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Wittmann CW, et al. Science, 2001 Jul 27. PMID 11408621
    4. Green fluorescent protein as a vital marker and reporter of gene expression in Drosophila. Yeh E, et al. Proc Natl Acad Sci U S A, 1995 Jul 18. PMID 7624365, Free PMC Article
    5. A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons. McLaughlin CN, et al. J Cell Biol, 2016 Aug 15. PMID 27502486, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Toll-6 and Spz are a new pair of guidance molecules mediating organ-specific metastatic behavior.
      Title: Spz/Toll-6 signal guides organotropic metastasis in Drosophila.
    2. elevated expression of Pav-KLP underlies transport and plasticity phenotypes in pathway mutants, indicating that Toll-6-FoxO signaling promotes MT dynamics by limiting Pav-KLP expression.
      Title: A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons.
    3. This study demonistrated that Toll-6 have neurotrophic functions in the Drosophila CNS matching those of DNT1 and DNT2 also pleiotropic functions, maintaining predominantly interneuron survival and regulating motor-axon targeting.
      Title: Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Roundabout binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotrophin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axis elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in convergent extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dendrite guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Toll-6
    Names
    CG7250-PA
    CG7250-PB
    CG7250-PC
    Toll-6-PA
    Toll-6-PB
    Toll-6-PC
    toll receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15336692..15344315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259837.3 → NP_001246766.1  Toll-6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246766.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NN49, Q9NBK9, Q9VUN0
      Conserved Domains (5) summary
      smart00255
      Location:1114 → 1247
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:350 → 729
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:401 → 626
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:279 → 302
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:883 → 943
      LRR_8; Leucine rich repeat

    2. NM_001259836.2 → NP_001246765.1  Toll-6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246765.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NN49, Q9NBK9, Q9VUN0
      Conserved Domains (5) summary
      smart00255
      Location:1114 → 1247
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:350 → 729
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:401 → 626
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:279 → 302
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:883 → 943
      LRR_8; Leucine rich repeat

    3. NM_079357.4 → NP_524081.1  Toll-6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524081.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NN49, Q9NBK9, Q9VUN0
      Related
      FBpp0075367
      Conserved Domains (5) summary
      smart00255
      Location:1114 → 1247
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:350 → 729
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:401 → 626
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:279 → 302
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:883 → 943
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RV9 Q95RV9
    Q9VUN0.1 Q9VUN0

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