Roc1a Regulator of cullins 1a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Roc1aprovided by FlyBase
Official Full Name: Regulator of cullins 1aprovided by FlyBase
Primary source: FLYBASE:FBgn0025638
Locus tag: Dmel_CG16982
See related: AllianceGenome:FB:FBgn0025638
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey65; BEST:CK01110; CG16982; CK01110; Dmel\CG16982; dRbx1; dRoc1; dRoc1a; EG:115C2.11; Rbx1; Rbx1/Roc; Roc; Roc1; ROC1; roc1a; Roc1alpha
Summary: Enables cullin family protein binding activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of neuron remodeling; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleus. Part of cullin-RING ubiquitin ligase complex. Is expressed in organism and wing disc. Orthologous to human RBX1 (ring-box 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1B13-1B13; 1-0 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (647304..648597)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (541337..542630)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY
Title: Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex.
Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase.
Title: Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase.
Roc1b, Roc1a and Roc2 proteins play nonredundant roles during development
Title: Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NEDD8 ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed
enables zinc ion binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in viral process	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Cul2-RING ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Cul3-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Cul4-RING E3 ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of cullin-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulator of cullins 1a

Names: CG16982-PA; CG16982-PC; CG16982-PD; Roc1a-PA; Roc1a-PC; Roc1a-PD; SCF-betaTrCP complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

647304..648597

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144671.3 → NP_001138143.2 regulator of cullins 1a, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138143.2

Status: REVIEWED

UniProtKB/TrEMBL

B7Z114

Conserved Domains (2) summary

COG5194
Location:53 → 136

APC11; Component of SCF ubiquitin ligase and anaphase-promoting complex [Posttranslational modification, protein turnover, chaperones / Cell division and chromosome partitioning]

pfam12678
Location:53 → 126

zf-rbx1; RING-H2 zinc finger
NM_001297825.1 → NP_001284754.1 regulator of cullins 1a, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284754.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77429, Q9W5E1

UniProtKB/TrEMBL

X2JA05

Conserved Domains (1) summary

cd16485
Location:40 → 101

mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins
NM_130496.4 → NP_569852.1 regulator of cullins 1a, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_569852.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77429, Q9W5E1

UniProtKB/TrEMBL

X2JA05

Related

FBpp0070117

Conserved Domains (1) summary

cd16485
Location:40 → 101

mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins