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    Elba1 Early boundary activity 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33669, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elba1provided by FlyBase
    Official Full Name
    Early boundary activity 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0000227
    Locus tag
    Dmel_CG12205
    See related
    AllianceGenome:FB:FBgn0000227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.70; bsg25A; Bsg25A; CG12205; clone 1.70; Dmel\CG12205; Elba; elba1
    Summary
    Contributes to chromatin insulator sequence binding activity and sequence-specific DNA binding activity. Involved in embryonic development via the syncytial blastoderm and heterochromatin boundary formation. Located in nucleus. Part of chromatin silencing complex. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; and ectoderm anlage. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Elba1 in Genome Data Viewer
    Location:
    25A3-25A3; 2-13 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4683052..4684461, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4683052..4684461, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long noncoding RNA: testis-specific 6 Neighboring gene uncharacterized protein Neighboring gene Early boundary activity 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and sequence analysis of the Drosophila blastoderm-specific gene bsg25A. Singer JB, et al. Gene, 1997 Sep 15. PMID 9332389
    2. A stage-specific factor confers Fab-7 boundary activity during early embryogenesis in Drosophila. Aoki T, et al. Mol Cell Biol, 2008 Feb. PMID 18039839, Free PMC Article
    3. The BEN Domain Protein Insensitive Binds to the Fab-7 Chromatin Boundary To Establish Proper Segmental Identity in Drosophila. Fedotova A, et al. Genetics, 2018 Oct. PMID 30082280, Free PMC Article
    4. BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila. Ueberschär M, et al. Nat Commun, 2019 Dec 13. PMID 31836703, Free PMC Article
    5. Bi-functional cross-linking reagents efficiently capture protein-DNA complexes in Drosophila embryos. Aoki T, et al. Fly (Austin), 2014. PMID 24135698, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stress-sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis.
      Title: Stress-sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis.
    2. Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.
      Title: Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to chromatin insulator sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin insulator sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic development via the syncytial blastoderm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in heterochromatin boundary formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    early boundary activity 1
    Names
    CG12205-PA
    Elba1-PA
    blastoderm-specific gene 25A
    early boundary factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4683052..4684461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078748.3 → NP_523472.2  early boundary activity 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523472.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01400, Q8SXI9, Q9VR17
      Related
      FBpp0077114
      Conserved Domains (1) summary
      smart01025
      Location:279 → 354
      BEN; The BEN domain is found in diverse animal proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JNF5 Q7JNF5
    Q9VR17.2 Q9VR17

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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