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    trk trunk [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trkprovided by FlyBase
    Official Full Name
    trunkprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003751
    Locus tag
    Dmel_CG5619
    See related
    AllianceGenome:FB:FBgn0003751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5619; Dmel\CG5619; fs(2)trunk; grk; Trk
    Summary
    Enables receptor ligand activity; torso binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in terminal region determination and torso signaling pathway. Located in extracellular space. Is expressed in nurse cell and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See trk in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10271443..10272324, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10271443..10272324, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Multi-substrate lipid kinase Neighboring gene Utx histone demethylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The torso ligand, unmasked? Stein D, et al. Sci STKE, 2001 Sep 4. PMID 11752676
    2. Noggin proteins are multifunctional extracellular regulators of cell signaling. Karunaraj P, et al. Genetics, 2022 May 5. PMID 35357435, Free PMC Article
    3. Torso RTK controls Capicua degradation by changing its subcellular localization. Grimm O, et al. Development, 2012 Nov. PMID 23048183, Free PMC Article
    4. Signaling gradients in cascades of two-state reaction-diffusion systems. Berezhkovskii AM, et al. Proc Natl Acad Sci U S A, 2009 Jan 27. PMID 19147842, Free PMC Article
    5. Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like. Henstridge MA, et al. Nat Commun, 2014 Mar 3. PMID 24584029

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Torso interacts with both Trunk and Torso-like, which cooperate to mediate dimerization and activation of Torso at the ends of the Drosophila embryo
      Title: Reconstitution of Torso signaling in cultured cells suggests a role for both Trunk and Torso-like in receptor activation.
    2. Present and other previous studies, suggest that the function of Tsl is to mediate secretion of Trk, thus providing the mechanism for spatially restricted activation of Tor in Drosophila embryos.
      Title: Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini.
    3. Data favours a scenario where Tsl functions post proteolytic processing of Trk to control localized terminal patterning.
      Title: Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like.
    4. Extracellular processing of the Trunk ligand at the anterior and posterior termini of the developing embryo activates the signaling pathway that defines the two ends.
      Title: The torso ligand, unmasked?
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables torso binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in terminal region determination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in terminal region determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in torso signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in torso signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in torso signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trunk
    Names
    CG5619-PA
    trk-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10271443..10272324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057419.3 → NP_476767.2  trunk [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476767.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24155, Q9VL09
      Related
      FBpp0079667
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24155.1 Q24155

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