Gdi2 GDP dissociation inhibitor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gdi2provided by MGI
Official Full Name: GDP dissociation inhibitor 2provided by MGI
Primary source: MGI:MGI:99845
See related: Ensembl:ENSMUSG00000021218 AllianceGenome:MGI:99845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GDIB; Gdi3; GDI-B
Summary: Contributes to GTPase activator activity. Acts upstream of or within small GTPase-mediated signal transduction. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 83.7), CNS E11.5 (RPKM 57.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A1; 13 1.98 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (3588075..3616261)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (3538075..3566261)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease.
Title: GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease.
Targeted disruption of Gdi2 causes early embryonic lethality.
Title: Targeted disruption of Gdi2 causes early embryonic lethality.
role in regulatory mechanism of neurotransmitter release
Title: [Regulatory mechanism of neurotransmitter release by low-molecular-weight G protein, Rab3A and the regulatory proteins].

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI645998 (e-PCR)
- UniSTS:164517

AI790193 (e-PCR)
- UniSTS:208885

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables Rab GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rab GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info
enables Rab GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IPI Inferred from Physical Interaction more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IPI Inferred from Physical Interaction more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	HDA more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rab GDP dissociation inhibitor beta

Names: GDI beta; GDI-2; GDI-3; RAB GDP dissociation inhibitor beta-2; guanosine diphosphate (GDP) dissociation inhibitor 2; guanosine diphosphate (GDP) dissociation inhibitor 3; guanosine diphosphate dissociation inhibitor 2; rab GDI beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.