Dmrta2 doublesex and mab-3 related transcription factor like family A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmrta2provided by MGI
Official Full Name: doublesex and mab-3 related transcription factor like family A2provided by MGI
Primary source: MGI:MGI:2653629
See related: Ensembl:ENSMUSG00000047143 AllianceGenome:MGI:2653629
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dmrt5
Summary: Enables identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of neuroblast proliferation; and stem cell fate specification. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human DMRTA2 (DMRT like family A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 8.1), CNS E14 (RPKM 5.1) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 51.37 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (109835222..109840896)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (109977989..109983691)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.
Title: Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.
Study suggests that DMRT3/5 function with EMX2 in positioning the pallial-subpallial boundary by antagonizing the ventral homeobox transcription factor GSX2.
Title: DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors.
Finely tuned levels of DMRT5, together with DMRT3, regulate patterning of the cerebral cortex.
Title: DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.
there is a link between Dmrta2 modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development
Title: The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
Dmrt5 is neurogenic, and reciprocally regulated by Lhx2; loss of either factor promotes gliogenesis.
Title: Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus.
Dmrt5 is a novel Wnt-dependent transcription factor required for early cortical development
Title: The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals.
data suggest that Dmrta2 plays pivotal roles in the early development of the telencephalon via the formation of the cortical hem, a source of Wnts, and also in the maintenance of neural progenitors as a downstream of the Wnt pathway
Title: The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex.
Dmrt5 is an important player in ventral mesencephalic neural fate specification
Title: Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Markers

Dmrta2 (e-PCR), detects polymorphism
- UniSTS:547209

Dmrta2 (e-PCR), detects polymorphism
- UniSTS:257213

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebral cortex regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor A2

Names: doublesex- and mab-3-related transcription factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172296.2 → NP_758500.2 doublesex- and mab-3-related transcription factor A2

See identical proteins and their annotated locations for NP_758500.2

Status: VALIDATED

Source sequence(s)

AI465212, AL627188, AY145837, CJ172393

Consensus CDS

CCDS18469.1

UniProtKB/Swiss-Prot

A2A9A2, Q8CFF8

Related

ENSMUSP00000060441.4, ENSMUST00000061187.4

Conserved Domains (2) summary

cd14418
Location:308 → 349

CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)

pfam00751
Location:65 → 111

DM; DM DNA binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

109835222..109840896

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503093.5 → XP_006503156.1 doublesex- and mab-3-related transcription factor A2 isoform X1

See identical proteins and their annotated locations for XP_006503156.1

UniProtKB/Swiss-Prot

A2A9A2, Q8CFF8

Conserved Domains (2) summary

cd14418
Location:308 → 349

CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)

pfam00751
Location:65 → 111

DM; DM DNA binding domain
XM_006503094.5 → XP_006503157.1 doublesex- and mab-3-related transcription factor A2 isoform X1

See identical proteins and their annotated locations for XP_006503157.1

UniProtKB/Swiss-Prot

A2A9A2, Q8CFF8

Conserved Domains (2) summary

cd14418
Location:308 → 349

CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)

pfam00751
Location:65 → 111

DM; DM DNA binding domain