Glis2 GLIS family zinc finger 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glis2provided by MGI
Official Full Name: GLIS family zinc finger 2provided by MGI
Primary source: MGI:MGI:1932535
See related: Ensembl:ENSMUSG00000014303 AllianceGenome:MGI:1932535
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nkl; Gli5; Klf16
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of smoothened signaling pathway and regulation of DNA-templated transcription. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; positive regulation of protein localization to nucleus; and regulation of transcription by RNA polymerase II. Located in non-motile cilium and nuclear speck. Is expressed in several structures, including early conceptus; gut; nervous system; oocyte; and retina layer. Used to study nephronophthisis 7. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 54.7), ovary adult (RPKM 24.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.45 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (4412217..4443076)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4594320..4625141)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease.
Title: Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease.
Long noncoding RNA Glis2 regulates podocyte mitochondrial dysfunction and apoptosis in diabetic nephropathy via sponging miR-328-5p.
Title: Long noncoding RNA Glis2 regulates podocyte mitochondrial dysfunction and apoptosis in diabetic nephropathy via sponging miR-328-5p.
GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation.
Title: GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation.
Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance.
Title: Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance.
Ring1A/B regulate and maintain AML stem cells in part by repressing Glis2 expression, which promotes their differentiation.
Title: Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.
Kif3a is required for cell cycle regulation and the DNA damage response, whereas cell senescence is significantly enhanced in Glis2 null cells.
Title: Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.
Glis2 can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity
Title: Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2).
Deficiency in Glis2 expression leads to tubular atrophy & progressive fibrosis, similar to nephronophthisis, that ultimately results in renal failure. Glis2 plays a critical role in the maintenance of normal kidney architecture and functions.
Title: Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions.
Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions
Title: Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis.
positive regulator of neuronal differentiation
Title: Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation involved in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein localization to nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: zinc finger protein GLIS2

Names: GLI-Kruppel family member GLI5; GLI-similar 2; Kruppel-like factor 16 (neuronal); neuronal Krueppel-like protein; zinc finger protein GLI5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031184.3 → NP_112461.2 zinc finger protein GLIS2

See identical proteins and their annotated locations for NP_112461.2

Status: VALIDATED

Source sequence(s)

AC087899, CF727873, CN703218, CX563691

Consensus CDS

CCDS27920.1

UniProtKB/Swiss-Prot

Q8R4X9, Q8VDL9, Q99MY6, Q99P73

Related

ENSMUSP00000014447.7, ENSMUST00000014447.13

Conserved Domains (2) summary

COG5048
Location:233 → 327

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:213 → 229

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

4412217..4443076

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246050.3 → XP_011244352.1 zinc finger protein GLIS2 isoform X8

Conserved Domains (3) summary

COG5048
Location:214 → 258

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:175 → 192

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:225 → 246

zf-H2C2_2; Zinc-finger double domain
XM_011246048.4 → XP_011244350.1 zinc finger protein GLIS2 isoform X6

Conserved Domains (3) summary

COG5048
Location:214 → 270

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:175 → 192

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:225 → 246

zf-H2C2_2; Zinc-finger double domain
XM_011246049.3 → XP_011244351.1 zinc finger protein GLIS2 isoform X7

Conserved Domains (3) summary

COG5048
Location:214 → 274

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:175 → 192

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:225 → 246

zf-H2C2_2; Zinc-finger double domain
XM_036160187.1 → XP_036016080.1 zinc finger protein GLIS2 isoform X4

Conserved Domains (3) summary

COG5048
Location:241 → 301

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:202 → 219

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:252 → 273

zf-H2C2_2; Zinc-finger double domain
XM_036160188.1 → XP_036016081.1 zinc finger protein GLIS2 isoform X5

Conserved Domains (3) summary

COG5048
Location:241 → 285

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:202 → 219

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:252 → 273

zf-H2C2_2; Zinc-finger double domain
XM_036160185.1 → XP_036016078.1 zinc finger protein GLIS2 isoform X1

Conserved Domains (2) summary

COG5048
Location:260 → 354

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:240 → 256

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036160186.1 → XP_036016079.1 zinc finger protein GLIS2 isoform X3

Conserved Domains (3) summary

COG5048
Location:241 → 297

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:202 → 219

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:252 → 273

zf-H2C2_2; Zinc-finger double domain
XM_006522768.5 → XP_006522831.1 zinc finger protein GLIS2 isoform X2

See identical proteins and their annotated locations for XP_006522831.1

UniProtKB/Swiss-Prot

Q8R4X9, Q8VDL9, Q99MY6, Q99P73

Conserved Domains (2) summary

COG5048
Location:233 → 327

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:213 → 229

ZF_C2H2; C2H2 Zn finger [structural motif]