Calcrl calcitonin receptor-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calcrlprovided by MGI
Official Full Name: calcitonin receptor-likeprovided by MGI
Primary source: MGI:MGI:1926944
See related: Ensembl:ENSMUSG00000059588 AllianceGenome:MGI:1926944
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRLR
Summary: Enables calcitonin gene-related peptide receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; heart development; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum; endosome; and lysosome. Predicted to be part of CGRP receptor complex and adrenomedullin receptor complex. Predicted to be active in neuronal dense core vesicle and plasma membrane. Is expressed in dorsal root ganglion; jugular lymph sac; and lung epithelium. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (calcitonin receptor like receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 53.6), bladder adult (RPKM 7.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.38 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (84160970..84255786, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (84330626..84425405, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
Title: CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
lymphatic insufficiency and lymphangiectasia caused by loss of lymphatic Calcrl exacerbates intestinal recovery following mucosal injury and underscores the importance of lymphatic function in promoting recovery from intestinal inflammation
Title: Lymphatic deletion of calcitonin receptor-like receptor exacerbates intestinal inflammation.
study reveals a Notch-Collagen V-Calcitonin receptor signalling cascade that maintains satellite cells in a quiescent state in a cell-autonomous fashion, and raises the possibility that similar reciprocal mechanisms act in diverse stem cell populations
Title: Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.
the cardiovascular response of Ramp1(-/-), Ramp2(+/-), Ramp3(-/-), Ramp1(-/-)/Ramp3(-/-) double-knockout (dKO), and Calcrl(+/-) mice to AM and CGRP were compared to wildtype mice.These results suggest that the hypotensive effect of AM is primarily mediated through the CLR/RAMP1 heterodimer, but that AM signaling via CLR/RAMP2 and CLR/RAMP3 also contributes to some hypotensive action.
Title: Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
Title: Spatial expression of components of a calcitonin receptor-like receptor (CRL) signalling system (CRL, calcitonin gene-related peptide, adrenomedullin, adrenomedullin-2/intermedin) in mouse and human heart valves.
these data indicate that the structural integrity of caveolae plays an important role in regulating subcellular distribution of CLR.
Title: The role of caveolae in regulating calcitonin receptor-like receptor subcellular distribution in vascular smooth muscle cells.
Calcrl deficiency results in multi-organ lymphangiectasia in adult mice.
Title: Characteristics of multi-organ lymphangiectasia resulting from temporal deletion of calcitonin receptor-like receptor in adult mice.
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3, but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR), and RAMP1 and RAMP2.
Title: Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice.
CTR is not only down regulated by signaling through the CTR but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins
Title: Expression of the calcitonin receptor, calcitonin receptor-like receptor, and receptor activity modifying proteins during osteoclast differentiation.
loss of calcrl in endothelial cells confirmed an essential role for AM signaling in vascular development.
Title: Adrenomedullin signaling is necessary for murine lymphatic vascular development.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV071593 (e-PCR)
- UniSTS:165180

BB235207 (e-PCR)
- UniSTS:185481

AB015595 (e-PCR)
- UniSTS:163289

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adrenomedullin binding	IEA Inferred from Electronic Annotation more info
enables adrenomedullin binding	ISO Inferred from Sequence Orthology more info
enables adrenomedullin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adrenomedullin receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenomedullin receptor activity	ISO Inferred from Sequence Orthology more info
enables calcitonin gene-related peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcitonin gene-related peptide receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables calcitonin gene-related peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables calcitonin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in adrenomedullin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenomedullin receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcitonin gene-related peptide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcitonin gene-related peptide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to sucrose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to sucrose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CGRP receptor complex	IEA Inferred from Electronic Annotation more info
part_of CGRP receptor complex	ISO Inferred from Sequence Orthology more info
part_of adrenomedullin receptor complex	ISO Inferred from Sequence Orthology more info
part_of adrenomedullin receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcitonin gene-related peptide type 1 receptor

Names: CGRP type 1 receptor; calcitonin receptor-like receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018782.2 → NP_061252.2 calcitonin gene-related peptide type 1 receptor precursor

See identical proteins and their annotated locations for NP_061252.2

Status: VALIDATED

Source sequence(s)

AF146525, AF209905, AK137210, CB595628, DY245973

Consensus CDS

CCDS16184.1

UniProtKB/Swiss-Prot

Q9QXH8, Q9R1W5, Q9WUP2

UniProtKB/TrEMBL

A2AR99

Related

ENSMUSP00000073875.3, ENSMUST00000074262.9

Conserved Domains (2) summary

cd15274
Location:137 → 410

7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:61 → 128

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

84160970..84255786 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499918.5 → XP_006499981.1 calcitonin gene-related peptide type 1 receptor isoform X1

See identical proteins and their annotated locations for XP_006499981.1

UniProtKB/Swiss-Prot

Q9QXH8, Q9R1W5, Q9WUP2

UniProtKB/TrEMBL

A2AR99

Conserved Domains (2) summary

cd15274
Location:137 → 410

7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:61 → 128

HRM; Hormone receptor domain
XM_036162403.1 → XP_036018296.1 calcitonin gene-related peptide type 1 receptor isoform X1

UniProtKB/Swiss-Prot

Q9QXH8, Q9R1W5, Q9WUP2

UniProtKB/TrEMBL

A2AR99

Conserved Domains (2) summary

cd15274
Location:137 → 410

7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:61 → 128

HRM; Hormone receptor domain