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    Lipo3 lipase, member O3 [ Mus musculus (house mouse) ]

    Gene ID: 381236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lipo3provided by MGI
    Official Full Name
    lipase, member O3provided by MGI
    Primary source
    MGI:MGI:2147592
    See related
    Ensembl:ENSMUSG00000024766 AllianceGenome:MGI:2147592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lipo1
    Summary
    Predicted to enable sterol ester esterase activity. Predicted to be involved in sterol metabolic process. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in embryo. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.6), lung adult (RPKM 2.2) and 28 other tissues See more
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    Genomic context

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    See Lipo3 in Genome Data Viewer
    Location:
    19 C1; 19 29.18 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (33532560..33568069, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (33555160..33590669, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene lipase, member O4 Neighboring gene 39S ribosomal protein L33, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_45976 Neighboring gene predicted gene 8978 Neighboring gene STARR-seq mESC enhancer starr_45977 Neighboring gene 39S ribosomal protein L33, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo). Holmes RS, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2010 Sep. PMID 20598663, Free PMC Article
    2. Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes. Kooistra MK, et al. Physiol Genomics, 2012 Jan 18. PMID 22045912
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sterol ester esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipase, member O3
    Names
    lipase, member O1
    NP_001013792.2
    XP_006527226.1
    XP_006527227.1
    XP_017173733.1
    XP_030106841.1
    XP_030106842.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013770.4 → NP_001013792.2  lipase, member O3 precursor

      See identical proteins and their annotated locations for NP_001013792.2

      Status: VALIDATED

      Source sequence(s)
      AI662771, AK139790
      Consensus CDS
      CCDS37961.1
      UniProtKB/TrEMBL
      Q3TD80, Q3UT41
      Related
      ENSMUSP00000108127.3, ENSMUST00000112508.9
      Conserved Domains (1) summary
      PLN02872
      Location:34 → 391
      PLN02872; triacylglycerol lipase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      33532560..33568069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527164.4 → XP_006527227.1  lipase, member O3 isoform X1

      See identical proteins and their annotated locations for XP_006527227.1

      UniProtKB/TrEMBL
      Q3TD80, Q3UT41
      Conserved Domains (1) summary
      PLN02872
      Location:34 → 391
      PLN02872; triacylglycerol lipase

    2. XM_017318244.3 → XP_017173733.1  lipase, member O3 isoform X3

      UniProtKB/TrEMBL
      Q3UXH6
      Conserved Domains (1) summary
      PLN02872
      Location:76 → 200
      PLN02872; triacylglycerol lipase

    3. XM_030250982.1 → XP_030106842.1  lipase, member O3 isoform X3

      UniProtKB/TrEMBL
      Q3UXH6
      Conserved Domains (1) summary
      PLN02872
      Location:76 → 200
      PLN02872; triacylglycerol lipase

    4. XM_030250981.2 → XP_030106841.1  lipase, member O3 isoform X2

      Conserved Domains (1) summary
      PLN02872
      Location:4 → 249
      PLN02872; triacylglycerol lipase

    5. XM_006527163.4 → XP_006527226.1  lipase, member O3 isoform X1

      See identical proteins and their annotated locations for XP_006527226.1

      UniProtKB/TrEMBL
      Q3TD80, Q3UT41
      Related
      ENSMUSP00000025694.7, ENSMUST00000025694.7
      Conserved Domains (1) summary
      PLN02872
      Location:34 → 391
      PLN02872; triacylglycerol lipase
    Nucleotide Protein Strain
    Heading Accession and Version

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