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    Wdr37 WD repeat domain 37 [ Mus musculus (house mouse) ]

    Gene ID: 207615, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wdr37provided by MGI
    Official Full Name
    WD repeat domain 37provided by MGI
    Primary source
    MGI:MGI:1920393
    See related
    Ensembl:ENSMUSG00000021147 AllianceGenome:MGI:1920393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Involved in lymphocyte homeostasis. Acts upstream of or within corpus callosum development. Predicted to be located in cytoplasm and nucleus. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in neurooculocardiogenitourinary syndrome. Orthologous to human WDR37 (WD repeat domain 37). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.0), whole brain E14.5 (RPKM 5.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdr37 in Genome Data Viewer
    Location:
    13 A1; 13 3.6 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (8853002..8922136, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (8802966..8872100, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33593 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene adenosine deaminase, RNA-specific, B2 Neighboring gene STARR-seq mESC enhancer starr_33594 Neighboring gene STARR-seq mESC enhancer starr_33595 Neighboring gene STARR-seq mESC enhancer starr_33596 Neighboring gene STARR-seq mESC enhancer starr_33598 Neighboring gene STARR-positive B cell enhancer ABC_E8888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:8870257-8870604 Neighboring gene STARR-seq mESC enhancer starr_33600 Neighboring gene STARR-seq mESC enhancer starr_33601 Neighboring gene STARR-seq mESC enhancer starr_33602 Neighboring gene STARR-seq mESC enhancer starr_33603 Neighboring gene ribosomal protein L10A, pseudogene 2 Neighboring gene isopentenyl-diphosphate delta isomerase Neighboring gene isopentenyl-diphosphate delta isomerase 2 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases. Nair-Gill E, et al. EMBO J, 2021 May 3. PMID 33630350, Free PMC Article
    2. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Kannan M, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078390, Free PMC Article
    3. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article
    4. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
    5. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases.
      Title: Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA0982, 6430603N07, 3110035P10Rik, 4933417A01Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lymphocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039388.2 → NP_001034477.1  WD repeat-containing protein 37 isoform a

      See identical proteins and their annotated locations for NP_001034477.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC132433, AK036203, BB611667, BY122174
      Consensus CDS
      CCDS26232.1
      UniProtKB/Swiss-Prot
      Q80Y96, Q8CBE3, Q8CCL2
      UniProtKB/TrEMBL
      Q3UK24
      Related
      ENSMUSP00000062174.7, ENSMUST00000054251.13
      Conserved Domains (2) summary
      cd00200
      Location:148 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:159 → 197
      7WD40; WD40 repeat [structural motif]

    2. NM_001039389.2 → NP_001034478.1  WD repeat-containing protein 37 isoform b

      See identical proteins and their annotated locations for NP_001034478.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC124732, AK044740, CJ134699
      Consensus CDS
      CCDS49204.1
      UniProtKB/TrEMBL
      Q05BF4, Q8C8P3
      Related
      ENSMUSP00000135742.2, ENSMUST00000176922.8

    3. NM_172445.3 → NP_766033.1  WD repeat-containing protein 37 isoform a

      See identical proteins and their annotated locations for NP_766033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC132433, AK036203, CJ134699
      Consensus CDS
      CCDS26232.1
      UniProtKB/Swiss-Prot
      Q80Y96, Q8CBE3, Q8CCL2
      UniProtKB/TrEMBL
      Q3UK24
      Related
      ENSMUSP00000021572.5, ENSMUST00000021572.11
      Conserved Domains (2) summary
      cd00200
      Location:148 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:159 → 197
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      8853002..8922136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516470.3 → XP_006516533.1  WD repeat-containing protein 37 isoform X1

      See identical proteins and their annotated locations for XP_006516533.1

      UniProtKB/Swiss-Prot
      Q80Y96, Q8CBE3, Q8CCL2
      UniProtKB/TrEMBL
      Q3UK24
      Conserved Domains (2) summary
      cd00200
      Location:148 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:159 → 197
      7WD40; WD40 repeat [structural motif]

    2. XM_036157955.1 → XP_036013848.1  WD repeat-containing protein 37 isoform X1

      UniProtKB/Swiss-Prot
      Q80Y96, Q8CBE3, Q8CCL2
      UniProtKB/TrEMBL
      Q3UK24
      Conserved Domains (2) summary
      cd00200
      Location:148 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:159 → 197
      7WD40; WD40 repeat [structural motif]

    3. XM_006516469.4 → XP_006516532.1  WD repeat-containing protein 37 isoform X1

      See identical proteins and their annotated locations for XP_006516532.1

      UniProtKB/Swiss-Prot
      Q80Y96, Q8CBE3, Q8CCL2
      UniProtKB/TrEMBL
      Q3UK24
      Conserved Domains (2) summary
      cd00200
      Location:148 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:159 → 197
      7WD40; WD40 repeat [structural motif]

    4. XM_006516471.5 → XP_006516534.1  WD repeat-containing protein 37 isoform X2

      UniProtKB/TrEMBL
      Q3UK24
      Conserved Domains (3) summary
      cd00200
      Location:103 → 441
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:114 → 152
      7WD40; WD40 repeat [structural motif]
      pfam05103
      Location:19 → 46
      DivIVA; DivIVA protein

    RNA

    1. XR_003950440.2 RNA Sequence

    2. XR_382013.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CBE3.1 GenPept UniProtKB/Swiss-Prot:Q8CBE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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