TED4 Plant heme oxygenase (decyclizing) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: TED4
Official Full Name: Plant heme oxygenase (decyclizing) family protein
Primary source: TAIR:AT2G26670
Locus tag: AT2G26670
See related: Araport:AT2G26670
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA HEME OXYGENASE 1; ATHO1; F18A8.4; F18A8_4; GENOMES UNCOUPLED 2; GUN2; HEME OXYGENASE; HEME OXYGENASE 1; HEME OXYGENASE 6; HO1; HY1; HY6; PLASTID HEME OXYGENASE; REVERSAL OF THE DET PHENOTYPE 4
Summary: Encodes a plastid heme oxygenase necessary for phytochrome chromophore biosynthesis and for coupling the expression of some nuclear genes to the functional state of the chloroplast.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See TED4 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 3

Sequence:: Chromosome: 2; NC_003071.7 (11341548..11343693)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abscisic acid-triggered guard cell l-cysteine desulfhydrase function and in situ hydrogen sulfide production contributes to heme oxygenase-modulated stomatal closure.
Title: Abscisic acid-triggered guard cell l-cysteine desulfhydrase function and in situ hydrogen sulfide production contributes to heme oxygenase-modulated stomatal closure.
The findings show that a novel ATX5-HY1-ABI4 module controls the glucose response in Arabidopsis thaliana.
Title: Trithorax-group protein ATX5 mediates the glucose response via impacting the HY1-ABI4 signaling module.
Data indicate that Heme oxygenase 1 (HY1) functioned negatively and acted upstream of ABSCISIC ACID-INSENSITIVE4 (ABI4) in drought signaling.
Title: Arabidopsis HY1-Modulated Stomatal Movement: An Integrative Hub Is Functionally Associated with ABI4 in Dehydration-Induced ABA Responsiveness.
HY1 confers cadmium tolerance by decreasing nitric oxide production and improving iron homeostasis.
Title: Arabidopsis HY1 confers cadmium tolerance by decreasing nitric oxide production and improving iron homeostasis.
Data indicate that AtHO1 (HY1; heme oxygenase-1)-overexpressing plants generated more NO, whereas knock-down of AtHO1 expression reduced the level of nitric oxide (NO) in plants.
Title: AtHO1 is involved in iron homeostasis in an NO-dependent manner.
HY1 mutant exhibited progressive salt hypersensitivity.
Title: Roles of NIA/NR/NOA1-dependent nitric oxide production and HY1 expression in the modulation of Arabidopsis salt tolerance.
Disrupting the binding of the AtHBP5 to haem oxygenase 1 (HY1) leads to oxidative stress.
Title: Disrupting the bimolecular binding of the haem-binding protein 5 (AtHBP5) to haem oxygenase 1 (HY1) leads to oxidative stress in Arabidopsis.
Mutation of HY1 causes UV-C hypersensitivity by impairing carotenoid and flavonoid biosynthesis and the down-regulation of antioxidant defence.
Title: Mutation of Arabidopsis HY1 causes UV-C hypersensitivity by impairing carotenoid and flavonoid biosynthesis and the down-regulation of antioxidant defence.
HY1 and HY5 additively regulate the expression of light regulated genes and accumulation of chlorophyll and anthocyanin during early seedling development.
Title: Functional interconnections of HY1 with MYC2 and HY5 in Arabidopsis seedling development.
HY1 (Heme oxygenase 1) plays an important role in salt acclimation.
Title: Evidence of Arabidopsis salt acclimation induced by up-regulation of HY1 and the regulatory role of RbohD-derived reactive oxygen species synthesis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_001124920.1

Supported by ESTs:

NM_128224.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme oxygenase (decyclizing) activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carotenoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to UV-C	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chloroplast-nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flavonoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phytochromobilin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within red, far-red light phototransduction	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within regulation of meristem growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of stomatal movement	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: Plant heme oxygenase (decyclizing) family protein

NP_001118392.1

REVERSAL OF THE DET PHENOTYPE 4 (TED4); FUNCTIONS IN: heme oxygenase (decyclizing) activity, heme binding; INVOLVED IN: regulation of meristem growth, heme oxidation, red, far-red light phototransduction, chloroplast-nucleus signaling pathway, phytochromobilin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053); BEST Arabidopsis thaliana protein match is: heme oxygenase 3 (TAIR:AT1G69720.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_180235.1

REVERSAL OF THE DET PHENOTYPE 4 (TED4); FUNCTIONS IN: heme oxygenase (decyclizing) activity, heme binding; INVOLVED IN: regulation of meristem growth, heme oxidation, red, far-red light phototransduction, chloroplast-nucleus signaling pathway, phytochromobilin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053), Haem oxygenase (decyclizing), plant (InterPro:IPR016951); BEST Arabidopsis thaliana protein match is: heme oxygenase 3 (TAIR:AT1G69720.1); Has 616 Blast hits to 616 proteins in 143 species: Archae - 0; Bacteria - 178; Metazoa - 207; Fungi - 2; Plants - 113; Viruses - 0; Other Eukaryotes - 116 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

11341548..11343693

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128224.3 → NP_180235.1 Plant heme oxygenase (decyclizing) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180235.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B3H4A6, O48782, Q7E9A5, Q9FPE3

UniProtKB/TrEMBL

A0A178VP48, A0A5S9X1F5

Conserved Domains (1) summary

cd19165
Location:73 → 280

HemeO; heme oxygenase in eukaryotes and some bacteria
NM_001124920.1 → NP_001118392.1 Plant heme oxygenase (decyclizing) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001118392.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O48782

Conserved Domains (1) summary

cd00232
Location:73 → 233

HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...