U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CLC2 Clathrin light chain protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818594, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CLC2
    Official Full Name
    Clathrin light chain protein
    Primary source
    TAIR:AT2G40060
    Locus tag
    AT2G40060
    See related
    Araport:AT2G40060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    clathrin light chain 2; T28M21.22; T28M21_22
    Summary
    Encodes a clathrin that is localized to the cortical division zone and the cell plate and colocalizes with TPLATE during cell plate anchoring.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CLC2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (16726424..16728207)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene nuclear RNA polymerase D1B Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene flocculation FLO11-like protein Neighboring gene ncRNA Neighboring gene EARLY FLOWERING-like protein (DUF1313)

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dynamic behavior of clathrin in Arabidopsis thaliana unveiled by live imaging. Ito E, et al. Plant J, 2012 Jan. PMID 21910772
    2. Clathrin regulates blue light-triggered lateral auxin distribution and hypocotyl phototropism in Arabidopsis. Zhang Y, et al. Plant Cell Environ, 2017 Jan. PMID 27770560
    3. New Gateway-compatible vectors for a high-throughput protein-protein interaction analysis by a bimolecular fluorescence complementation (BiFC) assay in plants and their application to a plant clathrin structure analysis. Nishimura K, et al. Biosci Biotechnol Biochem, 2015. PMID 26193449
    4. Dynamic analysis of Arabidopsis AP2 σ subunit reveals a key role in clathrin-mediated endocytosis and plant development. Fan L, et al. Development, 2013 Sep. PMID 23924631
    5. Clathrin light chains regulate hypocotyl elongation by affecting the polarization of the auxin transporter PIN3 in Arabidopsis. Hu T, et al. J Integr Plant Biol, 2021 Nov. PMID 34478221

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clathrin light chains regulate hypocotyl elongation by affecting the polarization of the auxin transporter PIN3 in Arabidopsis.
      Title: Clathrin light chains regulate hypocotyl elongation by affecting the polarization of the auxin transporter PIN3 in Arabidopsis.
    2. Loss of clathrin light chain 2 (CLC2) and CLC3 affects endocytosis and lateral distribution of PIN3 thereby impairing blue light-triggered establishment of asymmetric auxin distribution.
      Title: Clathrin regulates blue light-triggered lateral auxin distribution and hypocotyl phototropism in Arabidopsis.
    3. Majority of clathrin light chain with green fluorescent protein (CLC-GFP) is localized to the trans-Golgi network (TGN), and a minor population is associated with multivesicular endosomes and the Golgi trans-cisternae.
      Title: Dynamic behavior of clathrin in Arabidopsis thaliana unveiled by live imaging.
    4. Data indicate that MTV1 (AT3G16270) and AGD5 (AT5G54310) Physically Interact with clathrin.
      Title: MTV1 and MTV4 encode plant-specific ENTH and ARF GAP proteins that mediate clathrin-dependent trafficking of vacuolar cargo from the trans-Golgi network.
    5. At2g40060 regulates clathrin-mediated trafficking, auxin signaling, and development in Arabidopsis.
      Title: Clathrin light chains regulate clathrin-mediated trafficking, auxin signaling, and development in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    NM_129564.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in cell plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    part_of clathrin coat of coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin coat of trans-Golgi network vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Clathrin light chain protein
    NP_565921.1
    • Clathrin light chain protein; FUNCTIONS IN: structural molecule activity; INVOLVED IN: intracellular protein transport, vesicle-mediated transport; LOCATED IN: plasma membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Clathrin light chain (InterPro:IPR000996); BEST Arabidopsis thaliana protein match is: Clathrin light chain protein (TAIR:AT3G51890.1); Has 548 Blast hits to 536 proteins in 149 species: Archae - 2; Bacteria - 80; Metazoa - 210; Fungi - 41; Plants - 105; Viruses - 2; Other Eukaryotes - 108 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16726424..16728207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129564.3 → NP_565921.1  Clathrin light chain protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565921.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04209, Q8L9R8
      UniProtKB/TrEMBL
      A0A178W0Q3, A0A5S9X5L6
      Conserved Domains (1) summary
      pfam01086
      Location:62 → 221
      Clathrin_lg_ch; Clathrin light chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04209.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools