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    GLY1 NAD-dependent glycerol-3-phosphate dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818664, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLY1
    Official Full Name
    NAD-dependent glycerol-3-phosphate dehydrogenase family protein
    Primary source
    TAIR:AT2G40690
    Locus tag
    AT2G40690
    See related
    Araport:AT2G40690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    SFD1; SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY 1; T7D17.13; T7D17_13
    Summary
    Encodes a putative dihydroxyacetone phosphate (DHAP) reductase involved in glycerol-3-phosphate supply within the chloroplast for synthesis of glycerolipids. Mutants have reduced levels of hexadecatrienoic acid, which is rescued by exogenous glycerol-3-phosphate. This gene appears to be involved in the flux of fatty acids in the prokaryotic glyerolipid biosynthesis pathway.
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    Genomic context

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    See GLY1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (16973992..16976534)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene response regulator 16 Neighboring gene pseudo Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Over-expression of Arabidopsis thaliana SFD1/GLY1, the gene encoding plastid localized glycerol-3-phosphate dehydrogenase, increases plastidic lipid content in transgenic rice plants. Singh V, et al. J Plant Res, 2016 Mar. PMID 26747130, Free PMC Article
    2. The Arabidopsis thaliana dihydroxyacetone phosphate reductase gene SUPPRESSSOR OF FATTY ACID DESATURASE DEFICIENCY1 is required for glycerolipid metabolism and for the activation of systemic acquired resistance. Nandi A, et al. Plant Cell, 2004 Feb. PMID 14729910, Free PMC Article
    3. A new class of Arabidopsis mutants with reduced hexadecatrienoic acid fatty acid levels. Miquel M, et al. Plant Physiol, 1998 Jul. PMID 9662534, Free PMC Article
    4. Glycerol-3-phosphate metabolism in wheat contributes to systemic acquired resistance against Puccinia striiformis f. sp. tritici. Yang Y, et al. PLoS One, 2013. PMID 24312351, Free PMC Article
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis SFD1 localizes in rice plastids and its over-expression increases plastidic membrane lipid content in transgenic rice plants without any major impact on ER lipids.
      Title: Over-expression of Arabidopsis thaliana SFD1/GLY1, the gene encoding plastid localized glycerol-3-phosphate dehydrogenase, increases plastidic lipid content in transgenic rice plants.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001336857.1
    NM_001336858.1
    NM_129631.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycerolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycerolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerophospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast envelope HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NAD-dependent glycerol-3-phosphate dehydrogenase family protein
    NP_565939.1
    • GLY1; FUNCTIONS IN: glycerol-3-phosphate dehydrogenase [NAD+] activity; INVOLVED IN: systemic acquired resistance, glycerol-3-phosphate metabolic process, glycerolipid biosynthetic process, glycerolipid metabolic process; LOCATED IN: glycerol-3-phosphate dehydrogenase complex, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal (InterPro:IPR006109), NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal (InterPro:IPR011128), NAD-dependent glycerol-3-phosphate dehydrogenase (InterPro:IPR006168); BEST Arabidopsis thaliana protein match is: NAD-dependent glycerol-3-phosphate dehydrogenase family protein (TAIR:AT5G40610.1); Has 8663 Blast hits to 8662 proteins in 2795 species: Archae - 24; Bacteria - 5277; Metazoa - 643; Fungi - 297; Plants - 161; Viruses - 0; Other Eukaryotes - 2261 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16973992..16976534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129631.3 → NP_565939.1  NAD-dependent glycerol-3-phosphate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565939.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q949Q0
      UniProtKB/TrEMBL
      A0A178VQD1, A0A5S9X5T9
      Conserved Domains (1) summary
      PRK00094
      Location:87 → 413
      gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

    2. NM_001336858.1 → NP_001324724.1  NAD-dependent glycerol-3-phosphate dehydrogenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q949Q0
      UniProtKB/TrEMBL
      A0A178VQD1, A0A5S9X5T9
      Conserved Domains (1) summary
      PRK00094
      Location:87 → 413
      gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

    3. NM_001336857.1 → NP_001324723.1  NAD-dependent glycerol-3-phosphate dehydrogenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B101
      Conserved Domains (1) summary
      PRK00094
      Location:1 → 312
      gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q949Q0.1

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